Potassium Chloride Bufus, 40 mg/ml concentrate 10 ml 10 pcs

Potassium chloride is a remedy that replenishes potassium deficiency in the body.

Potassium chloride helps to maintain the necessary intra- and extracellular levels of potassium.

Potassium is the main intracellular ion and plays an important role in the regulation of various body functions.

Participates in maintaining intracellular osmotic pressure, in the processes of conduction and transmission of nerve impulse to innervated organs, in the contraction of skeletal muscles and in a number of biochemical processes.

Decreases myocardial excitability and conduction, in high doses it inhibits automatism.

Indications

Active ingredient

Composition

1 ml of solution for intravenous injection contains:

the active ingredient:

Potassium chloride – 40 mg

How to take, the dosage

Intravenously. In hypokalemia with cardiac arrhythmia – 1-1.5 g 4-5 times a day; after recovery of cardiac rhythm the dose is reduced.

In case of digitalis intoxication it is taken 2-3 g per day, in severe cases – up to 5 g. To stop paroxysmal tachycardia attacks on the first day – 8-12 g, with subsequent reduction to 3-6 g. Intravenously by jet, if necessary intravenous drip (slowly over 1 h > – 2-2.5 g in 500 ml of 5% dextrose solution.

For the prevention and treatment of ectopic arrhythmias in myocardial infarction – polarizing mixture: potassium chloride solution in 5% – 10% dextrose solution (insulin is added at the rate of 1 U per 3-4 g of dry dextrose).

Interaction

Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerance).

Magnifies negative dromo- and batmotropic effect of antiarrhythmic drugs.

As part of the polarizing mixture (in combination with dextrose and insulin) promotes normalization of heart rhythm in myocardial infarction, ectopic arrhythmias and overdose of cardiac glycosides.

Limits gynokalemia caused by glucocorticosteroids, mineralocorticosteroids and diuretics.

Beta-adrenoblockers, cyclosporine, potassium-saving diuretics, heparin, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs may increase the risk of developing hyperkalemia.

Special Instructions

During treatment it is necessary to monitor serum K+ content, ECG, in the treatment of hypokalemia – control of acid-base status.

The safety and effectiveness of potassium chloride administration in children have not been established.

If it is necessary to use during pregnancy the calculated benefit for the mother must be compared with the potential risk for the fetus.
During lactation the decision about stopping of breast-feeding must be made.

The diet high in sodium chloride increases the excretion of K+ from the body. Note that hyperkalemia, which is fatal, can develop rapidly and be asymptomatic.

Contraindications

Side effects

Nervous system disorders: paresthesias, muscle weakness, confusion.

Cardiovascular system: decreased blood pressure, arrhythmias, heart block, cardiac arrest.

Other: hyperkalemia, allergic reactions.

Overdose

Symptoms: hyperkalemia (muscle hypotonus, paresthesias of extremities, delayed atrioventricular conduction, arrhythmias, cardiac arrest).

The early clinical signs of hyperkalemia usually appear with a serum K+ concentration greater than 6 mEq/L; sharpening of the T wave, disappearance of the U wave, decreased ST segment, prolonged QT interval, and enlarged QRS complex. More severe symptoms of hyperkalemia – muscle paralysis and cardiac arrest – develop at K+ concentration of 9-10 mEq/L.

Treatment: orally or intravenously – NaCl solution; intravenously – 300-500 ml of 5% dextrose solution (with 10-20 units of insulin in 1 liter); if necessary – hemodialysis and peritoneal dialysis.

Similarities