Potassium Chloride Bufus, 40 mg/ml concentrate 10 ml 10 pcs

Potassium chloride is a remedy that replenishes potassium deficiency in the body.

Potassium chloride helps to maintain the necessary intra- and extracellular levels of potassium.

Potassium is the main intracellular ion and plays an important role in the regulation of various body functions.

Participates in maintaining intracellular osmotic pressure, in the processes of conduction and transmission of nerve impulse to innervated organs, in the contraction of skeletal muscles and in a number of biochemical processes.

Decreases myocardial excitability and conduction, in high doses it inhibits automatism.

Indications

Hypokalemia (including due to diabetes mellitus, prolonged diarrhea and/or vomiting, therapy with antihypertensive drugs, some diuretics, glucocorticosteroids),
treatment and prevention of digital intoxication,
prevention of arrhythmia in patients with myocardial infarction (in the acute period).

Pharmacological effect

Potassium chloride is a remedy that replenishes potassium deficiency in the body.

Helps maintain the necessary intra- and extracellular potassium levels.

Potassium is the main intracellular ion and plays an important role in the regulation of various body functions.

Participates in maintaining intracellular osmotic pressure, in the processes of conducting and transmitting nerve impulses to innervated organs, in the contraction of skeletal muscles and in a number of biochemical processes.

Reduces the excitability and conductivity of the myocardium, in high doses it inhibits automatism.

Special instructions

During the treatment period, it is necessary to monitor the K+ content in the blood serum, ECG, and when treating hypokalemia, control the acid-base state.

The safety and effectiveness of potassium chloride in children have not been established.

If it is necessary to use during pregnancy, the expected benefit for the mother should be compared with the potential risk for the fetus.
During lactation, the issue of stopping breastfeeding should be decided.

A diet high in sodium chloride increases the excretion of K+ from the body. It should be borne in mind that hyperkalemia, leading to death, can develop quickly and be asymptomatic.

Active ingredient

Potassium chloride

Composition

1 ml of solution for intravenous administration contains:

active ingredient:

potassium chloride – 40 mg

Contraindications

Hyperkalemia,
complete atrioventricular block,
adrenal insufficiency,
chronic renal failure,
concomitant therapy with potassium-sparing diuretics,
metabolic disorders (acidosis, hypovolemia with hyponatremia),
pregnancy,
lactation period,
age under 18 years (efficacy and safety have not been established).

Side Effects

From the nervous system: paresthesia, muscle weakness, confusion.

From the cardiovascular system: decreased blood pressure, arrhythmias, heart block, cardiac arrest.

Other: hyperkalemia, allergic reactions.

Interaction

Pharmaceutically compatible with solutions of cardiac glycosides (improves their tolerability).

Strengthens the negative dromo- and bathmotropic effect of antiarrhythmic drugs.

As part of a polarizing mixture (in combination with dextrose and insulin), it helps to normalize heart rhythm during myocardial infarction, ectopic arrhythmias and overdose of cardiac glycosides.

Eliminates gynokalemia caused by glucocorticosteroids, mineralocorticosteroids and diuretics.

Beta-blockers, cyclosporine, potassium-sparing diuretics, heparin, angiotensin-converting enzyme inhibitors, and nonsteroidal anti-inflammatory drugs may increase the risk of hyperkalemia.

Overdose

Symptoms: hyperkalemia (muscle hypotonicity, paresthesia of the extremities, slowing of atrioventricular conduction, arrhythmias, cardiac arrest).

Early clinical signs of hyperkalemia usually appear when serum K+ concentrations are more than 6 mEq/L; sharpening of the T wave, disappearance of the U wave, decrease in the ST segment, prolongation of the QT interval, expansion of the QRS complex. More severe symptoms of hyperkalemia – muscle paralysis and cardiac arrest – develop at a K+ concentration of 9-10 mEq/L.

Treatment: orally or intravenously – NaCl solution; intravenously – 300-500 ml of 5% dextrose solution (with 10-20 units of insulin per 1 liter); if necessary, hemodialysis and peritoneal dialysis.

Storage conditions

In a dry place, protected from light, at a temperature from 0 to +30 ° C.

Shelf life

3 years. Do not use after expiration date.

Manufacturer

Update of PFC JSC, Russia