Polyglucin, 6% 400 ml

High-molecular-weight dextran solutions with sodium chloride, glucose or mannitol are polyfunctional plasma replacement solutions.

They normalize hemodynamics and increase the volume of fluid in the bloodstream.

These low molecular weight dextran solutions improve microcirculation, decrease the aggregation of blood-forming elements and blood viscosity.

Dextran solutions containing mannitol also have osmodiuretic effect.

Indications

High-molecular-weight dextran solutions: expressed posthemorrhagic hypovolemia, hypovolemic shock due to trauma, blood loss during childbirth, as a result of ectopic pregnancy, etc. Hypovolemia due to plasma loss (burns, compression syndrome). Preoperative and postoperative prophylaxis of embolism.

Low molecular weight dextran solutions: microcirculatory disorders, traumatic shock, burn shock, compression syndrome. Septic shock. Plasma volume replacement for blood loss in pediatrics. To fill artificial blood circulation machines (in certain proportions with blood).

Dextran with a molecular weight of 1000: prevention of severe allergic reactions to IV administration of dextran solutions.

Composition

How to take, the dosage

The solutions of high molecular weight dextran are administered by IV at a rate of 60-80 drops per minute in an amount up to 2-2.5 liters (in case of significant blood loss – with additional blood infusion).

Low molecular weight dextran solutions when used as a blood substitute are usually administered in the same doses. In other cases, the daily dose should not exceed 20 ml/kg. The rate of IV infusion is determined by the indication and the severity of the patient’s condition.

Dextran with a molecular weight of 1000 is administered by IV (IV) stream to adults in a dose of 3 g (20 ml), in children – in a dose of 45 mg/kg (0.3 ml/kg) – 1-2 minutes before the IV infusion of dextran solution. The interval between the administration of dextran with molecular weight 1000 and infusion of dextran solution should not exceed 15 min.

If more than 15 minutes elapse, dextran with molecular weight 1000 should be re-injected. It may be administered before each infusion of dextran solution, especially if more than 48 h have elapsed since the previous infusion.

Special Instructions

Due to possible allergic reactions, it is recommended to administer the first 10-20 ml of the infusion solution slowly, observing the patient’s condition. Given the possibility of arterial hypertension, it should be borne in mind that appropriate means for intensive therapy may be required.

Dextran with a molecular weight of 1000 should not be diluted or mixed with dextran solutions for infusion.

Dextran with a molecular weight of 1000 may be administered by IV through the Y-tap or rubber tubing of the infusion system, provided there is no significant dilution of the drug during injection.

Contraindications

Skull trauma with increased intracranial pressure, cerebral hemorrhage and other cases where large amounts of fluid are not indicated. Oliguria and anuria due to organic kidney disease, heart failure, coagulation and hemostasis disorders, tendency to allergic reactions. For solutions with glucose – diabetes mellitus and other carbohydrate metabolism disorders.

Performance in renal function disorders

It is contraindicated in oliguria and anuria due to organic renal disease.

Side effects

Possible: allergic reactions.

Rarely: arterial hypotension.