Polyglucin, 6% 400 ml

High-molecular-weight dextran solutions with sodium chloride, glucose or mannitol are polyfunctional plasma replacement solutions.

They normalize hemodynamics and increase the volume of fluid in the bloodstream.

These low molecular weight dextran solutions improve microcirculation, decrease the aggregation of blood-forming elements and blood viscosity.

Dextran solutions containing mannitol also have osmodiuretic effect.

Indications

Solutions of high molecular weight dextran: severe posthemorrhagic hypovolemia, hypovolemic shock due to trauma, blood loss during childbirth, as a result of ectopic pregnancy, etc. Hypovolemia caused by loss of plasma (burns, compartment syndrome). Preoperative and postoperative embolism prevention.

Solutions of low molecular weight dextran: microcirculation disorders, traumatic shock, burn shock, compartment syndrome. Septic shock. Plasma volume replacement during blood loss in pediatrics. For filling artificial blood circulation machines (in certain proportions with blood).

Dextran with a molecular weight of 1000: prevention of severe allergic reactions to intravenous administration of dextran solutions.

Pharmacological effect

Solutions of high molecular weight dextran with sodium chloride, glucose or mannitol are multifunctional plasma-substituting solutions.

They normalize hemodynamics and increase the volume of fluid in the bloodstream.

Such solutions of low molecular weight dextran help improve microcirculation, reduce the aggregation of blood cells and blood viscosity.

Dextran solutions containing mannitol also have an osmo-diuretic effect.

Special instructions

Due to possible allergic reactions, the first 10-20 ml of infusion solution is recommended to be administered slowly, while monitoring the patient’s condition. Given the possibility of developing arterial hypertension, it should be borne in mind that appropriate means for intensive care may be required.

Dextran with a molecular weight of 1000 cannot be diluted or mixed with dextran solutions for infusion.

Dextran with a molecular weight of 1000 can be administered intravenously through the Y-shaped branch or rubber tubing of the infusion system, provided that significant dilution of the drug does not occur during the injection.

Active ingredient

Dextran average molecular weight 50000-70000

Composition

100 ml
dextran with a molecular weight of 50,000 to 70,000
6 g

Contraindications

Skull injuries with increased intracranial pressure, cerebral hemorrhage and other cases when the administration of large amounts of fluid is not indicated. Oliguria and anuria caused by organic kidney disease, heart failure, coagulation and hemostasis disorders, tendency to allergic reactions. For solutions with glucose – diabetes mellitus and other carbohydrate metabolism disorders.

Use for renal impairment

Contraindicated in oliguria and anuria caused by organic kidney disease.

Side Effects

Possible: allergic reactions.

Rarely: arterial hypotension.

Storage conditions

In a dry place, at a temperature of −10 to 20 °C

Shelf life

5 years

Manufacturer

Biokhimik JSC, Russia