Pimafucin, vaginal suppositories 100 mg 6 pcs

Pharmacological group

The drug with antifungal action for local use in gynecology.

Pharmacological action

Antifungal polyenic antibiotic of the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the cell membrane of the fungus, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

Natamycin is sensitive to most pathogenic yeast fungi, especially Candida albicans. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been noted in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, so it has no systemic action.

Indications

Vaginitis, vulvitis, vulvovaginitis, caused mainly by fungi of the genus Candida.

Pharmacological effect

Clinical and pharmacological group

A drug with antifungal action for topical use in gynecology.

Pharmacological action

Antifungal polyene antibiotic from the macrolide group, which has a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols in the cell membrane of the fungal cell, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

Most pathogenic yeasts, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been observed in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, and therefore does not have a systemic effect.

Special instructions

Precautions when taking the drug

Vaginal suppositories quickly dissolve under the influence of body temperature, forming a foamy mass, which contributes to the uniform distribution of the active substance.

In case of chronic or recurrent infection, local treatment can be supplemented by prescribing Pimafucin in the form of tablets and cream for external use.

Cetyl alcohol, which is included in vaginal suppositories, can cause a slight burning sensation if you are hypersensitive to this component.

During menstruation, suppository therapy is interrupted.

During the period of using suppositories, there is no need to avoid sexual intercourse. However, it is recommended to conduct an examination of sexual partners and, if candidiasis is detected, to conduct a course of treatment with Pimafucin. Also during the treatment period you should use barrier contraception.

Impact on the ability to drive vehicles and other mechanisms that require increased concentration

Pimafucin® does not affect the ability to drive vehicles or operate machinery.

Interaction with alcohol

There is no data on interaction with alcohol.

Conditions for dispensing from pharmacies

The drug is approved for use as an over-the-counter product.

Active ingredient

Natamycin

Composition

Vaginal suppositories are torpedo-shaped, from white with a yellowish tint to light yellow with a brownish tint.

1 suppository contains:

Active ingredients:

natamycin 100 mg.

Excipients:

cetyl alcohol – 690 mg,

solid fat – 700 mg,

sorbitan trioleate – 460 mg,

polysorbate 80 – 460 mg,

sodium bicarbonate – 69 mg,

adipic acid – 64 mg.

There are 3 suppositories in an aluminum foil strip.

The package contains 2 aluminum foil strips.

Pregnancy

It is possible to use Pimafucin during pregnancy and lactation.

There are no data on adverse effects on the fetus.

Contraindications

Contraindications to the use of Pimafucin are:

hypersensitivity to the components of the drug.

Side Effects

When using Pimafucin, the following are possible:

Local reactions: mild irritation, burning sensation.

Interaction

No drug interactions between Pimafucin® and other drugs have been detected.

Overdose

Currently, no cases of overdose of Pimafucin® have been reported.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

2 years

Manufacturer

Temmler Italia S.r.L., Italy