Pimafucin, vaginal suppositories 100 mg 3 pcs
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A antifungal polyenic antibiotic from the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the cell membrane of the fungus, disrupting its integrity and function, which leads to cell death.
Pharmacodynamics
Natamycin is sensitive to most pathogenic yeast fungi, especially Candida albicans. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been noted in clinical practice.
Pharmacokinetics
When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, so it has no systemic action.
Indications
Vaginitis, vulvovaginitis, vulvovaginitis, caused mainly by fungi of the genus Candida.
Active ingredient
Composition
Active ingredients:
Natamycin 100 mg.
Auxiliary substances:
Cetyl alcohol – 690 mg,
solid fat – 700 mg,
sorbitan trioleate – 460 mg,
polysorbate 80 – 460 mg,
sodium bicarbonate – 69 mg,
adipic acid – 64 mg.
How to take, the dosage
Prescribe 1 vaginal suppository for 3-6 days. The suppository is inserted into the vagina in the supine position, as deeply as possible, once a day at night.
In case of persistent vaginitis caused by Candida albicans Pimafucin® is additionally prescribed in the form of tablets for oral administration (1 tablet 4 times daily for 10-20 days) to sanitize the focus of Candida infection in the gut. Pimafucin® in a cream form is used for the treatment of candidiasis of the genital organs of the partner.
The duration of the treatment course is determined individually. After disappearance of symptoms of the disease it is recommended to continue treatment for a few more days.
Interaction
Drug interactions of the drug Pimafucin® with other medicinal products have not been found.
Special Instructions
Vaginal suppositories dissolve rapidly under the influence of body temperature, forming a frothy mass, which promotes uniform distribution of the active substance.
In cases of chronic or recurrent infection, local treatment may be supplemented by prescription of Pimafucin in the form of tablets and cream for external use.
Cetyl alcohol, which is included in the vaginal suppositories, may cause a mild burning sensation if there is hypersensitivity to this component.
The therapy with suppositories is interrupted during menstruation.
When using the suppositories it is not necessary to exclude sexual intercourse. However, it is recommended to conduct an examination of sexual partners and, if candidiasis is detected, to carry out a course of treatment with Pimafucin. Also, barrier contraception should be used during treatment.
Impact on the ability to drive vehicles and other mechanisms requiring high concentration
Pimafucin® does not affect the ability to drive vehicles and operate machinery.
Interaction with alcohol
There are no data on interaction with alcohol.
Prescription conditions of pharmacies
The drug is approved for over-the-counter use.
Contraindications
Hypersensitivity to the ingredients of the drug.
Side effects
When using Pimafucin:
Local reactions: mild irritation, burning sensation.
Overdose
At present, no cases of Pimafucin® overdose have been reported.
Similarities
Weight | 0.016 kg |
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Shelf life | 2 years |
Conditions of storage | At a temperature not exceeding 25 °C |
Manufacturer | Temmler Italia S.r.l., Italy |
Medication form | vaginal suppositories |
Brand | Temmler Italia S.r.l. |
Other forms…
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