Pimafucin, 2% cream 30 g

Clinical and Pharmacological Group

Antifungal drug for external use.

Pharmacological action

Antifungal polyenic antibiotic of the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the cell membrane of the fungus, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

The majority of pathogenic yeast fungi, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been noted in clinical practice.

Pharmacokinetics

In application to the skin and mucous membranes practically does not undergo systemic absorption, so it has no systemic action.

Indications

Fungal diseases of the skin and mucous membranes caused by pathogens sensitive to the drug (including vaginitis, vulvitis, vulvovaginitis, balanoposthitis caused by fungi of the genus Candida; candidiasis of the skin and nails; otitis externa, either primarily caused by fungi, or complicated by candidiasis; ringworm).

Pharmacological effect

Clinical and pharmacological group

Antifungal drug for external use.

Pharmacological action

Antifungal polyene antibiotic from the macrolide group, which has a wide spectrum of action. Has a fungicidal effect. Natamycin binds sterols in the cell membrane of the fungal cell, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

Most pathogenic yeasts, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been observed in clinical practice.

Pharmacokinetics

When applied to the skin and mucous membranes, it is practically not subject to systemic absorption, and therefore does not have a systemic effect.

Special instructions

Precautions when taking the drug

In case of chronic or recurrent infection, local treatment can be supplemented by the administration of Pimafucin in tablet form.

Use in pediatrics

Cream for external use Pimafucin® can be prescribed to newborns.

Interaction with alcohol

There is no data on interaction with alcohol.

Conditions for dispensing from pharmacies

The drug is approved for use as an over-the-counter product.

Active ingredient

Natamycin

Composition

Cream for external use 2% from white to light yellow.

1 g of cream contains:

Active ingredients:

natamycin 20 mg.

Excipients:

cetyl ether wax,

Decyloleate (cetiol V),

sodium lauryl sulfate,

propylene glycol,

propyl parahydroxybenzoate,

methyl parahydroxybenzoate,

cetostearyl alcohol,

purified water.

There are 30 g of cream in an aluminum or plastic tube.

The package contains 1 tube.

Contraindications

Contraindications to the use of Pimafucin are:

hypersensitivity to the components of the drug.

Side Effects

When using Pimafucin, the following are possible:

Local reactions: mild irritation, burning sensation.

Interaction

No drug interactions between Pimafucin® and other drugs have been detected.

Overdose

Currently, no cases of overdose of Pimafucin® have been reported.

Storage conditions

At a temperature not exceeding 25 °C

Shelf life

4 years

Manufacturer

Temmler Italia S.r.L., Italy