Pimafucin, 2% cream 30 g

Clinical and Pharmacological Group

Antifungal drug for external use.

Pharmacological action

Antifungal polyenic antibiotic of the macrolide group with a broad spectrum of action. It has a fungicidal effect. Natamycin binds sterols of the cell membrane of the fungus, disrupting its integrity and function, which leads to cell death.

Pharmacodynamics

The majority of pathogenic yeast fungi, especially Candida albicans, are sensitive to natamycin. Dermatophytes are less sensitive to natamycin. Resistance to natamycin has not been noted in clinical practice.

Pharmacokinetics

In application to the skin and mucous membranes practically does not undergo systemic absorption, so it has no systemic action.

Indications

Active ingredient

Composition

The cream for external use is 2% of white to light yellow color.

1 g of cream contains:

Active substances:

natamycin 20 mg.

Auxiliary substances:

Cetyl ether wax,

decyloleate (cetiol V),

How to take, the dosage

How to use and dosing regimen in different age groups and depending on the disease

In dermatomycosis (including candidiasis of the skin, diaper rash in children) the cream is applied to the affected skin surface once or several (up to 4) times a day.

In case of mycosis of the external auditory canal the affected surface is smeared with the cream once or several times (up to 4 times) a day. The ear is cleaned before applying the product. After using the drug, a tampon made of natural material (cotton, wool) is placed in the ear canal.

In case of vulvitis, vulvovaginitis, balanopostitis the cream is applied to the affected areas of the skin one or more times a day.

The duration of treatment is set individually. After the symptoms of the disease disappear it is recommended to continue treatment for a few more days.

Interaction

Drug interactions of Pimafucin® with other medicinal products were not detected.

Special Instructions

Precautions for use

In cases of chronic or recurrent infection, topical treatment may be supplemented with Pimafucin in tablet form.

Pediatric use

Pimafucin® cream for external use may be administered to infants.

Interaction with alcohol

There are no data on interaction with alcohol.

Prescription conditions of pharmacies

The drug is approved for over-the-counter use.

Contraindications

The contraindication to the use of Pimafucin is:

Side effects

When using Pimafucin, there may be:

Local reactions: mild irritation, burning sensation.

Overdose

At present, no cases of overdose of Pimafucin® have been reported.

Similarities