Pigenum, 40 mg 28 pcs.
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Pharmacotherapeutic group: Gastric gland secretion reducing agent – proton pump inhibitor
Pharmacological action
H+-K+-ATPase inhibitor. Blocks the final stage of hydrochloric acid secretion, reduces basal and stimulated (regardless of the type of irritant) secretion of hydrochloric acid in the stomach. In duodenal ulcer associated with Helicobacter pylori, this decrease in gastric secretion increases the sensitivity of the micro-organism to antibiotics. Pantoprazole has intrinsic antimicrobial activity against Helicobacter pylori.
Indications
Active ingredient
Composition
Shell composition: opadray yellow (hypromellose – 79.96%, povidone K25 – 1.52%, titanium dioxide – 1.4%, iron oxide yellow dye – 0.12%, propylene glycol – 17%) – 20 mg.
Composition of the enteric coating: copolymer of methacrylic acid and ethyl acrylate [1:1] (Eudragit L-30 D-55) – 14.2 mg, triethylcitrate – 1.48 mg.
How to take, the dosage
Interaction
In concomitant use pantoprazole may alter absorption of drugs whose absorption depends on the pH of the gastric contents (ketoconazole).
Because pantoprazole is metabolized in the liver by the cytochrome P450 enzyme system, the possibility of drug interaction with drugs metabolized by the same enzyme system cannot be excluded.
Special Instructions
The possibility of malignancy in the stomach and esophagus should be excluded before initiating therapy, because pantoprazole reduces symptoms and may delay a correct diagnosis. A diagnosis of reflux esophagitis requires mandatory endoscopic confirmation.
When used in patients with hepatic impairment, plasma liver enzyme activity should be monitored regularly and pantoprazole should be stopped if elevated.
Contraindications
Side effects
Digestive system: diarrhea; rarely – nausea, upper abdominal pain, flatulence.
CNS disorders: headache; rarely – weakness, dizziness; in isolated cases – initial manifestations of depression, visual disturbances.
Dermatological reactions: rarely – rash, itching.
Others: weakness, dizziness; in single cases – edema, increased body temperature.
Pregnancy use
If pantoprazole must be used during pregnancy, the estimated benefit to the mother and the potential risk to the fetus should be assessed.
If use during lactation is necessary, discontinuation of breastfeeding should be considered.
In experimental studies it has been found that pantoprazole is excreted with breast milk.
Similarities
Weight | 0.028 kg |
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Manufacturer | Sanovel Pharmaco-Industrial Trading Company, Turkey |
Medication form | enteric-soluble film-coated tablets |
Brand | Sanovel Pharmaco-Industrial Trading Company |
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