Phlebodia 600,600 mg 60+15 pcs.

Pharmacological group: Angioprotective agent.

Pharmacological properties:

The drug has a phlebotonic effect (reduces venous distensibility, increases venous tone (dose-dependent effect), reduces venous congestion), improves lymphatic drainage (increases the tone and frequency of contraction of lymph capillaries, increases their functional density, reduces lymphatic pressure), It improves microcirculation (increases capillary resistance (dose-dependent effect), decreases their permeability), reduces leukocyte adhesion to the venous wall and their migration to paravenous tissue, improves oxygen diffusion and perfusion in the skin tissue, has anti-inflammatory effect. It increases vasoconstrictor effect of adrenaline and noradrenaline, blocks the production of free radicals, synthesis of prostaglandins and thromboxane.

Pharmacokinetics:

Fast absorbed from the gastro-intestinal tract, found in plasma 2 hours after intake. Maximum plasma concentration is reached 5 hours after ingestion. It is evenly distributed and accumulated in all layers of the wall of the hollow veins and subcutaneous veins of the lower limbs, to a lesser extent in the kidneys, liver and lungs and other tissues. Selective accumulation of diosmin and/or its metabolites in the venous vessels reaches a maximum by 9 hours after administration and persists for 96 hours. Excreted by the kidneys 79%, by the intestine – 11%, with the bile – 2.4%.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications

Side effects

Pregnancy use

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