Phasostabil, 150 mg+30.39 mg 100 pcs

The mechanism of action of acetylsalicylic acid (ASA) is based on irreversible inhibition of cyclooxygenase (COX-1), resulting in blocked synthesis of thromboxane A2 and suppressed platelet aggregation. It is believed that ASA has other mechanisms to inhibit platelet aggregation, which expands the field of its use in various vascular diseases.

ASK also has anti-inflammatory, analgesic and antipyretic effects. The anti-inflammatory effect is associated with a decrease in blood flow due to inhibition of prostaglandin E2 synthesis. Magnesium hydroxide, which is part of the drug Fazostabil, has an antacid effect and protects the mucous membrane of the gastrointestinal tract from the effects of ASA.

Indications

– Primary prevention of cardiovascular diseases such as thrombosis and acute heart failure in the presence of risk factors (for example, diabetes mellitus, hyperlipidemia, hypertension, obesity, smoking, old age).

– Prevention of recurrent myocardial infarction and blood vessel thrombosis.

– Prevention of thromboembolism after vascular surgery (coronary artery bypass grafting, percutaneous transluminal coronary angioplasty).

– Unstable angina

Pharmacological effect

The mechanism of action of acetylsalicylic acid (ASA) is based on irreversible inhibition of cyclooxygenase (COX-1), as a result of which the synthesis of thromboxane A2 is blocked and platelet aggregation is suppressed. It is believed that ASA has other mechanisms for suppressing platelet aggregation, which expands the scope of its use in various vascular diseases.

ASA also has anti-inflammatory, analgesic, and antipyretic effects. The anti-inflammatory effect is associated with a decrease in blood flow due to inhibition of prostaglandin E2 synthesis. Magnesium hydroxide, which is part of the drug Fazostabil, has an antacid effect and protects the mucous membrane of the gastrointestinal tract from the effects of ASA.

Active ingredient

Acetylsalicylic acid, [Magnesium hydroxide]

Composition

1 tablet contains:

active substance:

acetylsalicylic acid – 75.00 mg;

magnesium hydroxide – 15.20 mg,

acetylsalicylic acid – 150.00 mg;

magnesium hydroxide – 30.39 mg.

Contraindications

– Hypersensitivity to ASA, excipients of the drug and other non-steroidal anti-inflammatory drugs (NSAIDs);

– Hemorrhage in the brain;

– Tendency to bleeding (vitamin K deficiency, thrombocytopenia, hemorrhagic diathesis);

– Chronic heart failure of functional class III-IV according to the NYHA classification;

– Bronchial asthma induced by taking salicylates and NSAIDs;

– Complete or incomplete combination of bronchial asthma, recurrent nasal polyposis and paranasal sinuses, and intolerance to ASA or other NSAIDs, including cyclooxygenase-2 (COX-2) inhibitors (including a history);

– Erosive and ulcerative lesions of the gastrointestinal tract (in the acute phase);

– Gastrointestinal bleeding;

– Severe renal failure (creatinine clearance (CC) less than 30 ml/min.);

– Liver failure (class B and C according to the Child-Pugh classification);

– Pregnancy (I and III trimesters), breastfeeding period;

– Glucose-6-phosphate dehydrogenase deficiency;

– Concomitant use with methotrexate (more than 15 mg per week);

– Children under 18 years of age.

Manufacturer

Ozon, Russia