Paracetamol Reneval, tablets 500 mg 20 pcs
€3.00 €2.73
Pharmacotherapeutic group: analgesic non-narcotic.
ATC code [N02BE01]
Pharmacological properties
Paracetamol has analgesic and antipyretic effect. Paracetamol blocks cyclooxygenase I and II only in CNS, affecting centers of pain and thermoregulation (in inflamed tissues cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase), which explains the almost complete absence of anti-inflammatory effect.
The lack of effect on prostaglandin synthesis in peripheral tissues determines the absence of its negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal mucosa. The possibility of methemoglobin formation is unlikely.
Indications
Moderate or mild pain syndrome (headache, dental pain, migraine pain, neuralgia, myalgia). Increased body temperature due to colds and other infectious and inflammatory diseases.
Pharmacological effect
Pharmacotherapeutic group: analgesic non-narcotic drug.
ATX code [N02BE01]
Pharmacological properties
Paracetamol has analgesic and antipyretic effects. Paracetamol blocks cyclooxygenase I and II only in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase), which explains the almost complete absence of anti-inflammatory effect.
The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa. The possibility of methemoglobin formation is unlikely.
Special instructions
Distorts laboratory test results when quantifying uric acid levels in plasma.
To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption.
The risk of developing liver damage increases in patients with alcoholic hepatosis.
With prolonged use of the drug, monitoring of the peripheral blood picture and the functional state of the liver is necessary.
Active ingredient
Paracetamol
Composition
1 tablet contains:
active substance:
paracetamol – 0.5 g
excipients:
potato starch – 0.0280 g
stearic acid – 0.0011 g
low molecular weight povidone – 0.0165 g
magnesium stearate – 0.0044 g
Contraindications
Hypersensitivity to paracetamol.
Children’s age up to 8 years.
With caution – renal and liver failure, benign hyperbilirubinemia (including Gilbert’s syndrome), viral hepatitis, alcoholic liver damage, alcoholism, pregnancy, lactation, old age, glucose-6-phosphate dehydrogenase deficiency.
Side Effects
Nausea, vomiting, epigastric pain, allergic reactions (skin rash, itching, urticaria, Quincke’s edema).
Rarely – anemia, leukopenia, thrombocytopenia, agranulocytosis.
Interaction
Stimulators of microsomal oxidation in the liver (phenytoin, ethanol, barbiturates, rifampicin, phenylbutazone, tricyclic antidepressants), ethanol and hepatotoxic drugs increase the production of hydroxylated active metabolites, which makes it possible to develop severe intoxications with small overdoses. Long-term use of barbiturates reduces the effectiveness of paracetamol.
Overdose
Symptoms: during the first 24 hours after administration – pallor of the skin, nausea, vomiting, anorexia, abdominal pain; impaired glucose metabolism, metabolic acidosis. Symptoms of liver dysfunction may appear 12-48 hours after an overdose.
In case of severe overdose – liver failure with progressive encephalopathy, coma, death; acute renal failure with tubular necrosis (including in the absence of severe liver damage); arrhythmia, pancreatitis. The hepatotoxic effect in adults occurs when taking 10 g or more.
Treatment: administration of SH-group donors and precursors of glutathione synthesis – methionine 8-9 hours after an overdose and N-acetylcysteine - 12 hours later. The need for additional therapeutic measures (further administration of methionine, intravenous administration of N-acetylcysteine) is determined depending on the concentration of paracetamol in the blood, as well as the time elapsed after its administration.
Storage conditions
Store in a dry place, protected from light and out of reach of children, at a temperature not exceeding + 25 ° C.
Shelf life
3 years
Manufacturer
Update of PFC JSC, Russia
Shelf life | 3 years |
---|---|
Conditions of storage | Store in a dry, protected from light and out of the reach of children, at a temperature not exceeding + 25 ° C. |
Manufacturer | Update PFC AO, Russia |
Medication form | pills |
Brand | Update PFC AO |
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