Oxyprogesterone, 12.5% 1 ml 10 pcs

Oxyprogesterone is an analog of the corpus luteum hormone (progesterone). It differs chemically from progesterone in that it contains a capronic acid residue at position 17. Being an ester of hydroxyprogesterone, it is metabolized slower than progesterone (has a longer-lasting effect).

After a single injection of an oil solution in m/m its effect lasts from 7 to 14 days. By its biological properties it is similar to progesterone. It binds with receptors on the surface of target organs and penetrates into the nucleus, where it stimulates RNA synthesis by activating DNA.

It promotes the transition of the mucous membrane of the uterus from the phase of proliferation caused by follicular hormone to the secretory phase and after fertilization it creates the necessary conditions for implantation and development of the fertilized egg.

Limits the excitability and contractility of the uterine muscles and fallopian tubes and stimulates the development of mammary gland terminal elements.

Indications

Conditions associated with corpus luteum deficiency:

threatened and incipient miscarriage (prevention and treatment),
amenorrhea (primary and secondary),
dysfunctional uterine bleeding.

Pharmacological effect

Oxyprogesterone is an analogue of the corpus luteum hormone (progesterone). Chemically different from progesterone in that it contains a caproic acid residue at position 17. Being an ester of hydroxyprogesterone, progesterone is metabolized more slowly (has a longer lasting effect).

After a single intramuscular injection of the oil solution, its effect lasts from 7 to 14 days. Its biological properties are similar to progesterone. By binding to receptors on the surface of cells of target organs, it penetrates into the nucleus, where, activating DNA, it stimulates RNA synthesis.

Promotes the transition of the uterine mucosa from the proliferation phase caused by follicular hormone to the secretory phase, and after fertilization creates the necessary conditions for implantation and development of a fertilized egg.

Reduces the excitability and contractility of the muscles of the uterus and fallopian tubes, stimulates the development of the end elements of the mammary gland.

Active ingredient

Hydroxyprogesterone caproate

Composition

1 ampoule with 1 ml of injection solution in peach or olive oil contains hydroxyprogesterone capronate 125 mg (12.5%) mg.

Contraindications

hepatitis,
liver failure,
breast and genital cancer,
tendency to thrombosis.

With caution. Cardiovascular diseases, arterial hypertension, chronic renal failure, diabetes mellitus, bronchial asthma, epilepsy, migraine, depression; hyperlipoproteinemia, ectopic pregnancy, lactation period.

Side Effects

From the nervous system: drowsiness, headache, depression, apathy, dysphoria.

From the digestive system: cholestatic hepatitis, nausea, vomiting, loss of appetite, calculous cholecystitis.

From the genitourinary system: decreased libido, shortened menstrual cycle, intermediate bleeding.

From the senses: visual impairment.

From the cardiovascular system: increased blood pressure, edema, thromboembolism (including pulmonary artery and cerebral vessels), thrombophlebitis, retinal vein thrombosis.

From the endocrine system: galactorrhea, alopecia, weight gain, enlargement, pain and tension of the mammary glands; hirsutism. Allergic reactions.

Local reactions: pain at the injection site.

Storage conditions

In a place protected from light

Shelf life

5 years

Manufacturer

Dalkhimfarm, Russia