Oxacillin, 1000 mg 50 pcs

Name: Oxacillin, 1000 mg 50 pcs
SKU: 501224
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EAN: 4602565015305 SKU: 501224 Categories: Antibiotics, Medicine

Description

Pharmacotherapeutic group: Semisynthetic penicillin antibiotic

ATC:

J.01.C.F Penicillins resistant to beta-lactamases

J.01.C.F.04 Oxacillin

Pharmacodynamics:

Oxacillin is an antibacterial agent from the group of semisynthetic penicillins.

Oxacillin has a bactericidal effect by inhibiting the synthesis of the bacterial cell wall. It is resistant to the action of penicillinase.

Active against Gram-positive microorganisms: Staphylococcus spp. (including penicillinase-producing), Streptococcus spp, including Streptococcus pneumoniae, Corynebacterium diphtheriae, Bacillus anthracis, anaerobic spore-forming bacilli, Gram-negative cocci (Neisseria gonorrhoeae, Neisseria meningitidis), Actinomyces spp.

Inactive against most gram-negative bacteria, rickettsiae, viruses, protozoa, fungi.

Pharmacokinetics:

Absorption is rapid and complete. Stable in a slightly acidic environment. The binding to plasma proteins is about 90%.

The half-life of the drug is 30 minutes.

The time of reaching the maximum concentration of the drug in plasma is 1-2 hours, the concentration decreases rapidly by 4 hours.

In pleural fluid it is found in concentrations up to 10%, in synovial and ascitic fluid – 50%, in bile – 5-8% in relation to its concentration in blood serum. It does not penetrate through the intact blood-brain barrier, while at inflammation of the cerebral membranes penetration increases. It penetrates through the placental barrier and is found in breast milk.

More than 40% of the drug after per oral administration is quickly excreted by the kidneys, with the bile – 10%.

Indications

Infectious diseases caused by penicillinase-producing and non-penicillinase-producing Gram-positive microorganisms (mainly staphylococci) (including septicemia, pneumonia, empyema, abscesses, phlegmons, cholecystitis, pyelitis, cystitis, osteomyelitis, postoperative wound infections, infected burns, etc.).

The drug is also prescribed in mixed infections when there are simultaneously benzylpenicillin-sensitive and benzylpenicillin-resistant Gram-positive microorganisms, bacterial endocarditis.

It is inappropriate to use oxacillin in infections caused by benzylpenicillin-sensitive staphylococci.

Active ingredient

Composition

How to take, the dosage

The daily dose for adults and children over 6 years of age is 2-4 g, for infants and prematurely born children – 20-40 mg/kg.

Until 3 months it is 60-80 mg/kg, from 3 months to 2 years -1 g, from 2 to 6 years – 2 g.

The daily dose is administered in 3-4 doses, with an interval of 6-8 hours. If necessary the indicated doses can be increased by 1.5-2 times.

When preparing solutions for intramuscular administration a bottle with 500 mg of oxacillin is filled with 3 ml of water for injection.

The duration of treatment is usually 7-10 days. In severe forms of the disease (sepsis, septic endocarditis and others) treatment may last from 2 to 6 weeks.

Interaction

Increases toxicity of methotrexate (competition for tubular secretion); concomitant use with calcium folinate (antidote of folic acid antagonists) may require longer use.

The combination of ampicillin or benzylpenicillin with oxacillin is rational because the latter, inhibiting penicillinase activity, thereby reduces the destruction of ampicillin and benzylpenicillin.

The spectrum of action with this combination becomes broader.

The combined use with other drugs with hepatotoxic effects should be avoided.

It is not recommended to use with bacteriostatic antibiotics at the same time (reduced effectiveness).

Drugs that block tubular secretion increase the concentration of oxacillin in the blood.

Special Instructions

The drug has no adverse effect on the ability to drive vehicles and operate machinery.

Contraindications

Hypersensitivity to oxacillin, penicillins and other beta-lactam antibiotics, period of lactation.

Allergic reactions in the history and/or bronchial asthma, chronic renal failure, enterocolitis against the background of antibiotics (in the history), pregnancy.

Side effects

In administration of oxacillin allergic reactions (skin itching, urticaria, angioneurotic edema, bronchospasm, anaphylactic shock, eosinophilia); dyspepsia (nausea, vomiting, diarrhea); pseudomembranous colitis, oral candidiasis, vaginal candidiasis; hepatotoxic effect – more often develops when prescribed in doses above 6 g/day (hyperthermia, nausea, vomiting, jaundice of sclerae or skin, increased activity of “liver” transaminases); hematuria, proteinuria, interstitial nephritis.

Overdose

Symptoms: disorders of gastrointestinal tract function and water-electrolyte balance.

Treatment: symptomatic. Hemodialysis is effective.

Pregnancy use

In pregnancy, use only if the estimated benefit to the mother is greater than the potential risk to the fetus.

In pregnancy and lactation, prescribe only for “vital” indications.

If it is necessary to prescribe the drug during lactation, breastfeeding should be stopped.

Additional information

Weight	0.830 kg
Shelf life	2 years. The drug should not be used after the expiration date.
Conditions of storage	In a dry place, protected from light and out of the reach of children, at a temperature not exceeding 20 ° C.
Manufacturer	Sintez OAO, Russia
Medication form	solution for injections and infusions
Brand	Sintez OAO