Ovipol Clio, vaginal suppositories 0.5 mg 15 pcs

Estrogen synthesized in the human body. Getting into the bloodstream it forms a complex with specific receptors (in uterus, vagina, urethra, breast, liver, hypothalamus, pituitary gland), stimulates the synthesis of DNA and proteins. It has a selective effect, mainly on the cervix, vagina, vulva, causes increased proliferation of vaginal and cervical epithelium, stimulates its blood supply, helps to restore the epithelium in its atrophic changes in the periods of premenopause and menopause, normalizes the pH of the vaginal environment, vaginal microflora, increases the resistance of its epithelium to infectious and inflammatory processes, affects the quality and quantity of cervical mucus. The effect on the endometrium is insignificant (minor risk of uterine bleeding).

It has a hypolipidemic effect, slightly increases the concentration of beta-lipoproteins in the blood, increases the sensitivity to insulin, improves glucose utilization, stimulates the production of liver globulins that bind sex hormones, renin, HDL and clotting factors. Due to participation in the realization of positive and negative feedback in the hypothalamic-pituitary-ovarian system, estriol is able to cause moderately pronounced central effects; it stimulates parasympathic-mimetic reactions.

Pharmacokinetics

Absorption is high. Time to reach Cmax in blood plasma with intravaginal administration is 1-2 hours. Binding with plasma albumin is 90%.

The excretion is mainly by the kidneys as metabolites (a few hours after intake and lasts up to 18 hours), 2% is excreted unchanged in the intestine.

Indications

Active ingredient

Composition

Active ingredient:

estriol500 mcg;

Auxiliary substance:

Semisynthetic glycerides (Supocir type) – 1999.5 mg

How to take, the dosage

Intravaginally, before going to bed.

In cases of lower urogenital tract mucosal atrophy, 1 suppository (0.5 mg) daily for the first 2-3 weeks, then the dose is gradually reduced based on symptoms, 1 suppository (0.5 mg) 2 times a week.

Pre- and postoperative therapy in postmenopausal women is 1 suppository (0.5 mg) for 2 weeks before or after surgery.

As a diagnostic agent, 1 suppository every other day for a week before the next smear.

If the next dose of the drug was missed, it should be taken immediately. However, if this occurs only on the day of the next dose, continue with the normal regimen without making up for the missed dose. Do not use 2 doses on the same day.

Interaction

Microsomal oxidation inducers (phenobarbital, carbamazepine, phenytoin, rifampicin, rifabutin, nevirapine, efavirenz) increase estrogen metabolism; powerful inhibitors (ritonavir, nelfinavir) significantly inhibit metabolism.

St. John’s wort preparations can induce estrogen metabolism.

Estriol increases the effect of hypolipidemic drugs.

Limits the effects of male sex hormones, anticoagulants, antidepressants, diuretics, hypotensive, hypoglycemic agents.

Contraindications

Hypersensitivity, thrombosis (venous and arterial), embolism, marked liver dysfunction, hormone-dependent tumors of the uterus or mammary glands, uterine bleeding of unknown etiology, otosclerosis, severe pruritus or cholestatic jaundice, as well as an increase in their manifestations during previous pregnancy or with the use of steroid drugs, pregnancy.

Side effects

Tension or pain in the mammary glands, fluid retention, nausea, cervical mucus hypersecretion, arterial hypertension, cramping of the calf muscles, headache, visual disturbances, pigmented spots on the skin; local irritation or itching (cream).

Similarities