Omez D, 10 mg+10 mg 30 pcs

Combination drug, contains domperidone – dopamine receptor blocker of central action and omeprazole – proton pump inhibitor. Domperidone Increases duration of peristaltic contractions of the antral part of the stomach and duodenum, accelerates gastric emptying if this process is slowed down, increases tone of the lower esophageal sphincter, eliminates the development of nausea and vomiting. Stimulates release of prolactin from the pituitary gland. Antiemetic effect is probably caused by combination of peripheral (gastrokinetic) action and antagonism to dopamine receptors in brain trigger zone.

Domperidone has no effect on gastric secretion. Domperidone poorly penetrates through the HEB, due to which the use of domperidone is rarely accompanied by the development of extrapyramidal side effects, especially in adults. Omeprazole Inhibits the enzyme H+-K+-ATPase (proton pump) in the parietal cells of the stomach and thus blocks the final stage of hydrochloric acid secretion. This leads to a decrease in the level of basal and stimulated secretion, regardless of the nature of the stimulus.

After a single oral administration of the drug the effect of omeprazole occurs within the first hour and lasts for 24 hours, the maximum effect is achieved after 2 hours. After discontinuation of the drug secretory activity is fully restored after 3-5 days. Pharmacodynamic substantiation of the combination Omeprazole inhibits hydrochloric acid secretion, domperidone increases the tone of the lower esophageal sphincter and accelerates gastric emptying, thus reducing the activity of aggressive factors of gastric juice and gastric contents throw into the esophagus.

Indications

Treatment of dyspepsia and gastroesophageal reflux that do not respond well to monotherapy with proton pump inhibitors or H2-receptor antagonists.

Composition

Composition per 1 capsule:

the active ingredients:

domperidone – 10 mg;

omeprazole (in pellets coated with enteric soluble film) – 10 mg;

auxiliary components:

magnesium stearate,

microcrystalline cellulose,

diethyl phthalate,

cetyl alcohol,

starch;

Gelatin capsule:

gelatin,

indigo carmine,

titanium dioxide,

methylparaben,

propylparaben,

carmosin,

sodium lauryl sulfate,

water.

How to take, the dosage

Overly with a small amount of water, 1 capsule 2 times a day, 15-20 minutes before a meal.

Interaction

Domperidone

Cimetidine, sodium bicarbonate, other antacids and antisecretory drugs decrease the bioavailability of domperidone.

Anticholinergic agents neutralize the effect of domperidone.

Increase the concentration of domperidone in plasma: azole antifungal agents, antibiotics from the group of macrolides, HIV protease inhibitors, nefazodone.

Omeprazole

May decrease absorption of esters, ampicillin, iron salts, itraconazole and ketoconazole (omeprazole increases gastric pH). As a cytochrome P450 inhibitor, it may increase concentration and decrease excretion of diazepam, indirect anticoagulants, phenytoin (drugs which are metabolized in liver by CYP2C19 cytochrome), that in some cases may require reducing their doses. Increases the inhibitory effect on the hematopoietic system of other drugs.

Special Instructions

Before therapy, it is necessary to rule out the presence of a malignant process in the gastrointestinal tract, because treatment, by masking symptoms, can delay a correct diagnosis.

Contraindications

Side effects

Pregnancy use