Ofloxacin-Solofarm, eye and ear drops 0.3% 5 ml
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Pharmacotherapeutic group:
Antimicrobial agent – fluoroquinolone
ATC:
S.01.A.E.01 Ofloxacin
J.01.M.A.01 Ofloxacin
Pharmacodynamics:
A broad spectrum antimicrobial agent of the group of fluoroquinolones, acts on the bacterial enzyme DNA-gyrease, which ensures superspiralization and thus stability of DNA-bacteria (destabilization of DNA chains leads to their death). It has a bactericidal effect. It is active against beta-lactamase-producing microorganisms and fast-growing atypical mycobacteria. Sensitive: Staphylococcus aureus (including strains), Staphylococcus epidermidis, Streptococcus pneumoniae. Streptococcus pyogenes, Enterococcus faecalis, Corynebacterium spp. Micrococcus spp., Bacillus spp., Enterobacteriaceae (Escherichia coli, Citrobacter, Enterobacter spp., Klebsiela spp., Proteus spp., Salmonella spp., Serratia spp, Shigella spp.), Pseudomonas aeruginosa and Pseudomonas species, Haemophilus influenza, Haemophilus ducreyi, Branhamella catarhalis, Neisseria gonorrhoeae, Neisseria menengitidis, Acinetobacter spp. Campylobacter spp., Gardenerella vaginalis, Helicobacter pylori, Brucella spp. The drug also shows activity against Chlamydia trachomatis, Chlamydia pneumoniae. Mycoplasma pneumoniae and some other mycoplasmas.
The Clostridium species, Bacteroides species and Peptococcus species are resistant. The resistance of Pseudomonas aeruginosa varies between 15-20% and the resistance of Staphylococcus aureus between 5-10%.
Pharmacokinetics:
4 hours after topical application, the average concentration of ofloxacin in tear fluid exceeds 2 µg/ml (the minimum concentration required to suppress growth in vitro by 90% for the most common strains of pathogens of infectious eye disease – MIC90).
Injection of ofloxacin into the ear when the eardrum is intact is accompanied by minimal absorption in the middle ear. However, uptake ofloxacin is increased with tympanic membrane perforations. After administration of 0.3% ofloxacin solution to adults with tympanic membrane perforations, the maximum serum concentration is 10 ng/ml.
The maximum serum concentration ofloxacin after 10 days of regular topical administration is 1000 times lower than with standard oral doses ofloxacin.
Indications
Active ingredient
Composition
1 ml of the drug contains:
The active ingredient:
Associates:
How to take, the dosage
Topically.
Infectious eye diseases
The drug is applied in 1 drop into the conjunctival sac of the diseased eye 2-4 times a day. It is not recommended that the drug be used for more than 2 weeks.
Ear infections
Adults and children over 12 years of age
The frequency of use of the drug and the duration of treatment are determined by the doctor individually.
In case of otitis externa, usually 10 drops are put into the affected ear 2 times a day for 10 days.
In the treatment of chronic suppurative otitis media with chronic tympanic membrane perforation, the recommended dose is 10 drops in the affected ear, 2 times a day, for 14 days.
Children 1-11 years of age
The frequency of use and duration of treatment are determined by the physician individually.
For the treatment of external otitis media and acute otitis media with a tympanostomy tube inserted, the recommended dose is 5 drops in the affected ear 2 times a day for 10 days.
Before instillation, warm the bottle in the hand for 1-2 minutes to avoid dizziness (possible with a cold solution). The instillation is done while the patient is lying on his or her side. After instillation the patient should remain in this position for 5 minutes to facilitate passage of the solution through the external auditory canal. If instillation in the other ear is necessary, proceed in a similar manner.
Interaction
Special Instructions
As with other antimicrobials, prolonged use of Ofloxacin can lead to the growth of flora that are insensitive to it. Therefore, if there is no clinical improvement during the standard treatment period or if the condition worsens, the drug should be withdrawn and alternative therapy should be started. Contact lenses should be removed prior to instillation and reinserted 20 minutes after instillation. The drug should not be injected subconjunctivally or into the anterior chamber of the eye.
Impact on ability to drive:
Patients who experience transient visual clarity impairment in their eyes after using the drug should not drive vehicles or machinery for 15 minutes after using the drug.
Contraindications
– Hypersensitivity to the components of the drug and other quinolone derivatives;
– non-bacterial diseases of the appendage, anterior and posterior segment of the eye;
– non-bacterial otitis media;
– childhood (less than 1 year);
– pregnancy, breastfeeding.
With caution:
Children’s age.
Side effects
After injection into the conjunctival sac, transient burning or discomfort in the eye, conjunctival hyperemia, blurred vision, pain in the eye, itching sensation may occur.
When used as ear drops, itching and a bitter taste in the mouth may occur. Eczema, paresthesia, dizziness, ear pain, ringing in the ears, dry mouth are extremely rare.
Overdose
Similarities
Weight | 0.020 kg |
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Shelf life | 3 years. After opening the bottle – 1 month. Do not use after the expiration date! |
Conditions of storage | Store at a temperature not exceeding 25 ° C. Keep out of reach of children. |
Manufacturer | Grotex Ltd, Russia |
Medication form | eye and ear drops |
Brand | Grotex Ltd |
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