Oflox, 200 mg 10 pcs

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Indications

Active ingredient

Composition

Active ingredient:

Ofloxacin – 200 mg.

Excipients:

Core: potato starch – 23mg, magnesium stearate – 3mg, microcrystalline cellulose – 54mg, povidone – 10mg

Film coating: ready-made water-soluble film coating – 15mg. (Shell composition: hydroxypropyl methylcellulose (hypromellose) – 3.75 mg, copovidone (copolyvidone) -3.375, polyethylene glycol 6000 (Macrogol 6000) – 1.425 mg, glyceryl caprylocaprate – 0.45 mg, polydextrose -2.25 mg, titanium dioxide – 3.75 mg.

How to take, the dosage

Ingestion. Doses are selected individually depending on the localization and severity of the infection. As well as the sensitivity of microorganisms, the general condition of the patient and the function of the liver and kidneys.

Adults – 200-800 mg per day, frequency of use – 2 times a day. A dose of up to 400 mg per day may be administered in 1 dose, preferably in the morning. In gonorrhea it is 400 mg once daily.

In patients with impaired renal function (with a creatinine clearance of 50-20 ml/min), the single dose should be 50% of the average dose with 2 times daily administration, or the full single dose administered once daily. If creatinine clearance is less than 20 ml/min, the single dose is 200 mg, then 100 mg per day every other day.

In hemodialysis and peritoneal dialysis, 100 mg every 24 hours. Maximum daily dose in hepatic failure is 400 mg/day.

The tablets are taken whole with water before or with a meal. Duration of treatment course is determined by pathogen sensitivity and clinical picture; treatment should be continued for at least 3 days after symptoms disappear and temperature normalizes completely. During treatment of salmonellosis the course of treatment is 7-8 days, in case of uncomplicated infections of the lower urinary tract the course of treatment is 3-5 days.

Interaction

Inhibits theophylline clearance by 25% (when using simultaneously theophylline dose should be reduced).

Increases the plasma concentration of glibenclamide.

Concomitant administration with vitamin K antagonists requires monitoring of the clotting system.

The risk of neurotoxic effects increases when prescribed with nonsteroidal anti-inflammatory drugs, nitroimidazole derivatives and methylxanthines.

The risk of tendon rupture increases when concomitantly prescribed with glucocorticosteroids, especially in the elderly.

The risk of crystalluria and nephrotoxic effects increases when prescribed with drugs that alkalize the urine (carboanhydrase inhibitors, citrates, sodium bicarbonate).

Special Instructions

It is not the drug of choice for pneumonia caused by pneumococci. It is not indicated in the treatment of acute tonsillitis.

It is not recommended to use for more than 2 months, exposure to sunlight, exposure to ultraviolet rays (mercury quartz lamps, solarium).

In case of side effects of the central nervous system, allergic reactions, pseudomembranous colitis, the drug should be stopped. In pseudomembranous colitis confirmed by colonoscopy and/or histology, oral administration of vancomycin and metronidazole is indicated.

Rarely occurring tendinitis may lead to tendon rupture (predominantly Achilles tendon), especially in elderly patients. If signs of tendinitis occur, treatment should be stopped immediately, the Achilles tendon should be immobilized, and an orthopedic surgeon should be consulted.

Women should not use tampons when using the drug, due to the increased risk of thrush.

The course of myasthenia gravis may worsen with treatment and increased incidence of porphyria in predisposed patients.

May lead to false-negative results in bacteriological diagnosis of tuberculosis (prevents isolation of Mycobacterium tuberculosis).

In patients with impaired hepatic or renal function it is necessary to monitor plasma concentration of Ofloxacin. In patients with severe renal or hepatic insufficiency the risk of toxic effects increases (dose adjustment is required).

Contraindications

Side effects

Gastrointestinal tract: gastralgia, anorexia, nausea, vomiting, diarrhea, flatulence, abdominal pain, increased activity of liver transaminases, hyperbilirubinemia, cholestatic jaundice, pseudomembranous enterocolitis.

Nervous system disorders: headache, dizziness, uncertainty of movements, tremor, convulsions, numbness and paresthesias of extremities, intense dreams, “nightmares” dreams, psychotic reactions, anxiety, state of agitation, phobias, depression, confusion, hallucinations, increased intracranial pressure.

Musculoskeletal system: tendinitis, myalgia, arthralgia, tenosynovitis, tendon rupture.

Sensory organs: color perception disorders, diplopia, disorders of taste, smell, hearing and balance.

Cardiovascular system: tachycardia, decreased blood pressure.

Allergic reactions: skin rash, itching, urticaria, allergic pneumonitis, allergic nephritis, eosinophilia, fever, Quincke’s edema, bronchospasm, Stevens-Johnson and Lyell syndrome, photosensitization, erythema multiforme exudative, anaphylactic shock.

Skin disorders: petechial hemorrhages (petechiae), bullous hemorrhagic dermatitis, papular rash with crust, indicating vascular lesions (vasculitis).

Hematopoietic organs: leukopenia, agranulocytosis, anemia, thrombocytopenia, pancytopenia, hemolytic and aplastic anemia.

Urinary system disorders: acute interstitial nephritis, renal dysfunction, hypercreatininemia, increased urea.

Others: dysbacteriosis, superinfection, hypoglycemia (in diabetic patients), vaginitis.

Overdose

Similarities