Noxpray, spray 0.05% 20 ml

Noxpray is an α-adrenomimetic, imidazoline derivative, refers to vasoconstrictors for local use.

In the nasal cavity, the drug narrows the arterioles of the nasal mucosa, as a result of which swelling, hyperemia, exudation decrease, nasal breathing restores, nasal secretions decrease.

Noxpray also reduces swelling of the mucous membrane around the orifice of the eustachian tube, improving drainage in eustachyitis and otitis media.

The essential oils included in the product help eliminate irritation of the nasal mucosa and protect it from excessive drying.

Pharmacokinetics

Local vasoconstriction of the nasal mucosa and sinuses occurs 5-10 minutes after injection of Noxpray into the nasal cavity and lasts up to 10-12 hours.

Indications

acute rhinitis of allergic or infectious-inflammatory etiology;
sinusitis;
nasal congestion and difficulty breathing through the nose due to colds;
eustachitis, otitis media;
to facilitate rhinoscopy and other manipulations in the nasal cavity.

Pharmacological effect

Noxprey is an α-adrenergic agonist, an imidazoline derivative, and is a vasoconstrictor for topical use.

When it enters the nasal cavity, the drug narrows the arterioles of the nasal mucosa, as a result of which swelling, hyperemia, exudation are reduced, nasal breathing is restored, and nasal discharge is reduced.

Noxprey also reduces swelling of the mucous membrane around the opening of the eustachian tube, improving drainage in cases of eustachitis and otitis media.

The essential oils included in the drug help eliminate irritation of the nasal mucosa and protect it from excessive drying.

Pharmacokinetics

Local constriction of the vessels of the nasal mucosa and paranasal sinuses occurs 5-10 minutes after injection of Noxprey into the nasal cavity and lasts up to 10-12 hours.

Special instructions

Use in pediatrics

Noxprey is used in children over 6 years of age.

Impact on the ability to drive vehicles and operate machinery

In recommended doses, the drug does not affect the speed of psychomotor reactions.

Active ingredient

Oxymetazoline

Composition

Active ingredients:

oxymetazoline hydrochloride 0.5 mg;

Excipients:

racemic camphor;

menthol;

eucalyptol;

sodium phosphate disubstituted;

sodium edetate (trilon B);

benzalkonium chloride;

propylene glycol;

purified water

oxymetazoline hydrochloride 500 mcg.

Pregnancy

During pregnancy and breastfeeding, the drug is used in cases of emergency, when the expected benefit to the mother outweighs the potential risk to the fetus or infant.

Contraindications

hypersensitivity to the components of the drug;
atrophic rhinitis;
children under 6 years of age;
pregnancy;
lactation period.

The drug should be used with caution in chronic heart failure, arrhythmia, severe atherosclerosis, arterial hypertension, thyrotoxicosis, diabetes mellitus, chronic renal failure, angle-closure glaucoma, prostatic hyperplasia with clinical symptoms; while taking MAO inhibitors and tricyclic antidepressants.

To prevent the spread of infection, one bottle should not be used by several people. Long-term use and overdose of the drug should be avoided. Long-term use of decongestants may reduce their effectiveness. Abuse of these drugs can cause atrophy of the nasal mucosa and reactive hyperemia with drug-induced rhinitis.

Side Effects

Sometimes: burning sensation or dryness of the nasal membranes, sneezing.

In rare cases: reactive hyperemia.

Repeated overdose with local nasal administration leads to systemic sympathomimetic effects such as tachycardia, insomnia, anxiety, increased blood pressure, headache, nausea.

It is extremely rare when using Noxprey that severe hypersensitivity reactions (including Quincke’s edema) may develop.

If side effects occur, you should stop using the drug and consult a doctor.

Interaction

Noxprey should not be used simultaneously with other local vasoconstrictors and intranasal agents, as well as with tricyclic antidepressants and MAO inhibitors.

Overdose

With a significant overdose or with accidental oral use, the following symptoms may be observed: miosis, nausea, vomiting, cyanosis, hyperthermia, tachycardia, arrhythmia, vascular insufficiency, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest, mental disorders. Extremely rare – depression of central nervous system functions with possible development of coma.

Treatment: in case of overdose of the drug, the stomach is washed and symptomatic therapy is carried out.

Storage conditions

The drug should be stored out of the reach of children at a temperature not exceeding 25°C.

Shelf life

3 years

Manufacturer

Sperko, Ukraine