Noxpray, spray 0.05% 20 ml

Noxpray is an α-adrenomimetic, imidazoline derivative, refers to vasoconstrictors for local use.

In the nasal cavity, the drug narrows the arterioles of the nasal mucosa, as a result of which swelling, hyperemia, exudation decrease, nasal breathing restores, nasal secretions decrease.

Noxpray also reduces swelling of the mucous membrane around the orifice of the eustachian tube, improving drainage in eustachyitis and otitis media.

The essential oils included in the product help eliminate irritation of the nasal mucosa and protect it from excessive drying.

Pharmacokinetics

Local vasoconstriction of the nasal mucosa and sinuses occurs 5-10 minutes after injection of Noxpray into the nasal cavity and lasts up to 10-12 hours.

Indications

Active ingredient

Composition

Active substances:

oxymetazoline hydrochloride 0.5 mg;

Associates:

camphor racemic;

menthol;

p> eucalyptol;

sodium phosphate displaced;

Sodium edetate (trilon B);

Benzalkonium chloride;

propylene glycol;

purified water

oxymetazoline hydrochloride 500 µg.

How to take, the dosage

The tip of the vial nozzle is inserted into each nasal passage and the vial is pressed sharply once. The air is drawn in through the nose while it is being injected. Do not tilt your head back or turn the bottle upside down when injecting Knoxpray.

Children between 6 and 12 years of age use 1 injection in each nasal passage 2 times a day, children over 12 years of age and adults use 1 to 2 injections in each nasal passage 2 times a day.

The duration of use should not exceed 7 days.

Interaction

Noxpray should not be used concomitantly with other topical vasoconstrictors and intranasal agents, as well as with tricyclic antidepressants and MAO inhibitors.

Special Instructions

Pediatric use

Noxpray is used in children over 6 years of age.

Impact on ability to drive and operate machinery

In the recommended doses, the drug does not affect the speed of psychomotor reactions.

Contraindications

With caution, use the drug in chronic heart failure, arrhythmia, marked atherosclerosis, arterial hypertension, thyrotoxicosis, diabetes, chronic renal failure, closed-angle glaucoma, prostatic hyperplasia with clinical symptoms; concomitant use of MAO inhibitors, tricyclic antidepressants.

The same vial should not be used by more than one person to prevent spread of infection. Prolonged use and overdose of the drug should be avoided. Prolonged use of antidepressants may decrease their effectiveness. Abuse of these agents may cause nasal mucosal atrophy and reactive hyperemia with medicated rhinitis.

Side effects

Occasionally: burning or dry nasal membranes, sneezing.

In rare cases: reactive hyperemia.

Multiple overdose with topical nasal administration leads to systemic sympathomimetic effects such as tachycardia, insomnia, anxiety, increased BP, headache, nausea.

In extremely rare cases, severe hypersensitivity reactions (including Quincke’s edema) may occur with Knoxpray.

If any side effects occur, discontinue use and see a physician.

Overdose

In case of significant overdose or accidental oral administration the following symptoms may be observed: miosis, nausea, vomiting, cyanosis, hyperthermia, tachycardia, arrhythmia, vascular failure, arterial hypertension, respiratory disorders, pulmonary edema, cardiac arrest, psychiatric disorders. Extremely rare – depression of CNS functions with possible development of coma.

Treatment: In case of overdose of the drug the stomach is flushed and symptomatic therapy is carried out.

Pregnancy use

In pregnancy and breastfeeding, the drug is used when absolutely necessary, when the expected benefit to the mother exceeds the potential risk to the fetus or infant.

Similarities