Novocaine bufus, 5 mg/ml 5 ml 10 pcs

A local anesthetic with moderate anesthetic activity and a wide range of therapeutic action. Being a weak base, it blocks Na+-channels, prevents generation of impulses in the endings of sensitive nerves and conduction of impulses along the nerve fibers.

Changes the action potential in nerve cell membranes without a pronounced effect on resting potential. It suppresses not only pain impulses but also impulses of other modality.

By absorption and direct vascular injection into the blood stream it decreases the excitability of peripheral cholinergic systems, reduces the formation and release of acetylcholine from preganglionic terminations (has some ganglion blocking effect), eliminates spasm of smooth muscles, reduces myocardial and cerebral motor areas excitability.

When administered intravenously it has analgesic, hypotensive and antiarrhythmic effect (increases the effective refractory period, decreases excitability, automaticity and conduction). Eliminates descending inhibitory effects of reticular formation of the brainstem. Inhibits polysynaptic reflexes. May cause convulsions in high doses. It has short anesthetic activity (duration of infiltration anesthesia is 0.5-1 hour).

Pharmacokinetics

Subject to complete systemic absorption. The degree of absorption depends on the place and route of administration (especially on vascularization and blood flow velocity in the area of administration) and the final dose (amount and concentration).

It is rapidly hydrolyzed by plasma and liver esterases to form 2 main pharmacologically active metabolites: diethylaminoethanol (has moderate vasodilator effect) and para-aminobenzoic acid (is a competitive antagonist of sulfonamide chemotherapeutic agents and can weaken their antimicrobial action). The elimination half-life is 30-50 seconds, in the neonatal period – 54-114 seconds. It is excreted mainly by the kidneys in the form of metabolites, not more than 2% is excreted unchanged.

Indications

Infiltration anesthesia;

vagosympathetic cervical, paranephral, circular and paravertebral blockades.

Active ingredient

Composition

1 ml of the solution contains:
active ingredient:
procaine hydrochloride – 5 mg,
excipients:
hydrochloric acid
(0.1 M hydrochloric acid solution) – to pH 3.8-4.5,
water for injection – to 1 ml.

How to take, the dosage

For infiltration anesthesia 2.5 mg/ml, 5 mg/ml solutions are used; for anesthesia by Vishnevsky method (taut creeping infiltration) – 1.25 mg/ml, 2.5 mg/ml solutions.
To reduce absorption and prolong the action in local anesthesia 0.1% solution of epinephrine hydrochloride is administered additionally – 1 drop per 2-5-10 ml of procaine solution.

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Interaction

Special Instructions

Contraindications

Side effects

Overdose

Similarities