Norcalut, tablets 5 mg 20 pcs

The active ingredient of Norcalut, norethisterone, is basically a norsteroid of the gestagenic type. Compared to other known gestagens, although it is not one of the most active gestagens, its properties are unusually favorable for therapy.

In the so-called “delay of menses” test, which is used to determine the effectiveness of gestagens, the drug shows properties of weak gestagens. The compound was found to be a medium-intensity progestive steroid in the Hammerstein test, as well as in the Clauberg test, which measures the dose required to transform the endometrium.

In contrast to many gestagenic compounds, norethisterone also has a pronounced anti-estrogenic character, and unlike other norethisterone derivatives, only a small portion of the compound is converted to estrogen in the body.

At the same time, Paulsen observed gynecomastia in men and breast enlargement in women under the influence of norethisterone. In addition to the main gestagenic action, a weak androgenic property of the compound has also been determined. According to clinical-pharmacological studies, norethisterone blocks the production of follicle stimulating hormone (FSH) and corpus luteum hormone (LH) and reduces steroid synthesis by the corpus luteum.

Norethisterone, which has a mainly gestagenic property, showing significant anti-estrogenic and minimal estrogenic and androgenic effects, can be very widely used in obstetrics and gynecology.

Indications

Premenstrual syndrome, mastodynia, cycle disorders accompanied by a shortened period of secretion, dysfunctional uterine bleeding, cystic glandular endometrial hyperplasia, endometriosis, adenomyosis, cessation and prevention of lactation, delayed menstruation, climax, in case of individual need oral contraception.

Active ingredient

Composition

1 tablet contains:

Active substance:

5 mg norethisterone.

How to take, the dosage

In cases of premenstrual syndrome, mastodynia, and irregular cycles, 1-2 pills are prescribed from day 16 of the cycle to day 25 of the cycle; this dosage may be supplemented with estrogen.

In case of dysfunctional uterine bleeding, cystic endometrial hyperplasia (if the functional origin of the bleeding is confirmed by histological analysis carried out in 6-month interval) in order to stop bleeding 1-2 tablets daily for 6-12 days are prescribed. To prevent recurrence, from the 16th day of the cycle to the 25th day of the cycle, 1-2 pills per day are prescribed, usually along with estrogen. In the case of a malignant process, Norcolut therapy is not used.

In cases of endometriosis, adenomyosis from day 5 to day 25 of the cycle it is taken on 1 tablet a day for 6 months or continuously from day 5 of the cycle up to 1/2 tablet a day, increasing the dose by 1/2 tablet every 2-3 weeks for 4-6 months.

To stop lactation in days 1-3 by 4 tablets, in days 4-7 by 3 tablets, in days 8-10 by 2 tablets. For menopausal symptoms, it is prescribed for a long time (months) 1 tablet a day, or, in case of failure, it is used in combination with 25-50 mcg ethinylestradiol. For oral contraception, 1/4-1/2 pills of Norcalut and 0.05 mg of ethinylestradiol are used, starting on the 5th day of the cycle for 21 days, and then after a 7-day break the course is repeated. If a 2-phase contraceptive dosage is needed, a 1/4 tablet of Norcolut for 10 days beginning on the 5th day of the cycle, then 1/2 tablet of Norcolut and 0.05 mg of ethinylestradiol for 11 days.

To delay menstruation, treatment begins 8 days before the expected menstruation and continues for 12 days: with 2 tablets of Norcolut per day prescribed, this dosage provides about 7-8 days of delayed menstruation.

Interaction

Drugs that activate microsomal liver enzymes (barbiturates, etc.) accelerate the metabolism and weaken the effect;

On the contrary, inhibitors (cimetidine, etc.) enhance it.

Contraindications

Predisposition to thrombosis, hepatitis, disorders of liver function, malignant tumors of the breast and genital organs.

Side effects

Rare and in further cycles passing: nausea, gastrointestinal complaints, unscheduled bleeding, sometimes edema, allergic skin reactions, paresthesias, weight changes, fatigue.