Nomides, 75 mg capsules 10 pcs

Nomides is an antiviral drug that contains oseltamiviracarboxylate, which inhibits influenza A and B viruses. As a result, it inhibits: the release of newly formed viral particles from infected cells, their penetration into respiratory epithelial cells and the further spread of the virus in the body.

Indications

Active ingredient

Composition

Active Substance:

How to take, the dosage

Interaction

Clinically significant drug interactions are unlikely according to pharmacological and pharmacokinetic studies. Oseltamivir phosphate is highly converted to active metabolite under the action of esterases mainly located in the liver. Drug interactions caused by competition for binding to active esterase centers are not widely reported in the literature.

The low degree of binding of oseltamivir and the active metabolite to plasma proteins does not suggest interactions related to displacement of drugs from binding to proteins. In vitro studies show that neither oseltamivir phosphate nor its active metabolite is a preferred substrate for polyfunctional cytochrome P450 oxidases or for glucuronyltransferases.

There is no reason for interaction with oral contraceptives. Cimetidine, a nonspecific inhibitor of cytochrome P450 system isoenzyme and competes in the process of tubular secretion with alkaline and cationic drugs, does not affect plasma concentrations of oseltamivir and its active metabolite. Clinically significant interdrug interactions related to competition for tubular secretion are unlikely, given the safety margin for most such drugs, the excretion pathways of the active metabolite of oseltamivir (glomerular filtration and anionic tubular secretion), and the excretion capacity of each pathway.

Probenecid leads to an increase in the AUC of the active metabolite of oseltamivir by approximately 2-fold (due to a decrease in active renal tubular secretion). However, no dose adjustment is required when concomitant use with probenecid, given the safety margin of the active metabolite.

Concomitant administration with amoxicillin does not affect plasma concentrations of oseltamivir and its components, showing little competition for excretion by anionic tubular secretion.

Concomitant administration with paracetamol does not affect plasma concentrations of oseltamivir and its active metabolite or paracetamol. No pharmacokinetic interactions between oseltamivir, its main metabolite were found when concomitantly taken with paracetamol, acetylsalicylic acid, cimetidine or antacids (magnesium and aluminum hydroxide, calcium carbonate), warfarin, rimantadine or amantadine.

. When using Osaltemivir with commonly used drugs such as angiotensin-converting enzyme inhibitors (enalapril, captopril), thiazide diuretics (bendroflumethiazide), antibiotics (penicillin, cephalosporins, azithromycin, erythromycin and doxycycline), H2-histamine receptor blockers (ranitidine, cimetidine), beta-adrenoblockers (propranolol), xanthines (theophylline), sympathomimetics (pseudoephedrine), opiates (codeine), glucocorticosteroids, inhaled bronchodilators and non-narcotic analgesics (acetylsalicylic acid, ibuprofen and paracetamol), no changes in the nature or frequency of adverse events were observed.

Oseltamivir in combination with drugs with narrow therapeutic scope (e.g., chlorpropamide, methotrexate, butadione) should be used with caution.

Special Instructions

Extemporaneous preparation of Nomides® suspension from capsules

. In cases where adults, adolescents and children have trouble swallowing the capsules or where there are signs of “aging” of the capsules, you should open the capsule and pour its contents into a small amount (maximum 1 teaspoon) of a suitable sweetened food (chocolate syrup with normal or no sugar content honey, light brown sugar or table sugar dissolved in water, sweet dessert, condensed milk with sugar, apple puree or yogurt) to mask the bitter taste. The mixture should be thoroughly mixed and given to the patient whole. The mixture should be swallowed immediately after preparation.

Capsules 75 mg

If patients require a dose of 75 mg, the following instructions should be followed:

1. Holding one 75 mg capsule of Nomides® over a small container, gently open the capsule and pour the powder into the container.

2. Add a small amount (no more than 1 teaspoon) of a suitable sweetened food (to mask the bitter taste) and mix well.

3. Stir the mixture thoroughly and drink it immediately after preparation. If a small amount of mixture remains in the container, you should rinse the container with a small amount of water and drink the remaining mixture.

If patients require doses of 30-60 mg, the following instructions should be followed for proper dosing:

1. Holding one 75 mg capsule of Nomides® over a small container, gently open the capsule and pour the powder into the container.

2. add 5 ml of water to the powder, using a syringe marked with the amount of liquid taken. Stir thoroughly for 2 minutes.

3. Draw the desired amount of mixture from the container into the syringe according to the following table.

Body weight

Recommended dose

/p>

30 mg

2 ml

>15-23 kg

45 mg

3 mL

>23-40 kg

60 mg

4 ml

There is no need to take the undissolved white powder because it is an inactive filler. Pressing the syringe plunger, inject all of its contents into the second reservoir. The unused mixture must be discarded.

4. Add a small amount (max 1 teaspoon) of a suitable sweetened food item to the second cup, to mask the bitter taste, and mix well.

5. Stir the mixture thoroughly and drink it immediately after preparation. If there is a small amount of mixture left in the container, you should rinse the container with a little water and drink the remaining mixture.

This process needs to be repeated before each dose.

Contraindications

Side effects

Overdose

In most cases of overdose during clinical trials and during postmarketing use of oseltamivir there were no adverse events.

In the remaining cases, overdose symptoms were consistent with the adverse events presented in the section “Adverse effects”.

Similarities