Noltrexin endoprosthesis synovial fluid sterile 2 ml syringe

Mechanism of action NOLTREXIN acts by restoring the volume and viscosity of synovial fluid in the joints affected by osteoarthritis. As a result, the pain syndrome is relieved and joint mobility improves. The peculiarity of the endoprosthesis is its longer action as compared to pharmaceuticals and materials.

Biodegradation of polyacrylamide gel occurs through macrophage resorption and non-cellular lysis. Subjected to very slow biodegradation for more than 6 months. It is excreted mainly through the kidneys and liver without tissue damage. Implant metabolites (using radioactive tags) are detected in the urine and liver. Due to the safety of the drug and the practical absence of a tissue reaction, the implant does not need to be removed. The position and orientation of the implant in the joint cavity is not determined radiologically. If necessary, the implant can be removed by puncture and lavage of the joint cavity.

Indications

Composition

Interaction

Directions for use

Injection of 2.5 ml to 10.0 ml into the knee joint in one to four injections of 2.5 ml at one-week intervals. Recommended technique:

Pelvic joint: two injections of 2.5 ml or one injection of 5.0 ml. The recommended interval between injections is one week.

The method of administration is calculated individually depending on the stage of osteoarthritis and at the discretion of the physician.

The multiple injections into the knee joint while the patient is seated have the potential to damage the cartilage covering the articular surfaces and menisci with a large-diameter needle.

In order to avoid overfilling the joint with dense, slowly resorbable material, it is recommended that the course be discontinued when the clinical result is good!

Courses should be repeated every 6 to 24 months depending on clinical manifestations.

The repeat course of injections may be shortened as indicated.

In other joints, the endoprosthesis is injected at 2.5 ml or less, depending on the size of the joint.

Special Instructions

The treatment procedure is similar to other intraarticular injections with minimal risk of complications (inflammation, arthralgia, internal bleeding due to vascular trauma).

Perform normal precautions: the prosthesis may only be injected in a clean dressing room or operating room by qualified medical personnel. Keep out of the reach of children!

Synopsis

Side effects