Nimica, 100 mg 20 pcs.

Nymica is a non-steroidal anti-inflammatory drug (NSAID) of the sulfonanilide class. It has anti-inflammatory, analgesic and antipyretic effects.

Nimisulide belongs to new generation of NSAIDs, the mechanism of action of which is connected with selective inhibition of cyclooxygenase II and influence on several other factors: inhibition of platelet-activating factor, tumor necrosis factor alpha, inhibition of proteinases and histamine.

Pharmacokinetics

In oral administration, it is well absorbed from the gastrointestinal tract. The maximum concentration of the active substance in plasma is reached 1.5-2.5 hours after taking the drug.

The use of the drug concomitantly with food reduces the absorption rate, but does not affect its degree. Binding to plasma proteins is 99%, the volume of distribution is 0.19-0.35 l/kg. Nimesulide is actively metabolized in the liver with the formation of several metabolites, excreted mainly in the urine (70%) and feces (30%).

In patients with renal insufficiency (creatinine clearance 30-80 ml/min) and in children and elderly patients pharmacokinetic profile of nimesulide did not change significantly.

Indications

Active ingredient

Composition

1 tablet contains:

The active ingredients:

nimesulide – 100 mg

Auxiliary substances:

Starch,

Microcrystalline cellulose,

Colloidal silicon dioxide,

gelatinized starch,

citric acid monohydrate,

purified talc,

sodium salt of starch glycolate,

aspartame,

How to take, the dosage

Orally

The maximum dose for children is 5 mg/kg/day in 2-3 doses.

Interaction

Caution should be exercised when using Nimesulide concomitantly with:

Special Instructions

With caution, use simultaneously with diuretics, blood pressure medications, other analgesic anti-inflammatory drugs, anti-diabetic drugs.

Contraindications

Side effects

Nervous system and sensory organs: rarely – headache, dizziness, somnolence.

Cardiovascular system and blood (hematopoiesis, hemostasis): very rare – thrombocytopenia.

Gastrointestinal system disorders: rarely – nausea, heartburn, stomach pain, tarry stools, melena.

Skin disorders: rarely – petechiae, purpura.

Urogenital system disorders: rarely – oliguria.

Allergic reactions: exanthema, erythema, urticaria.

Pregnancy use

Nimica is contraindicated in pregnancy and lactation.

Similarities