Nifuratel-SZ, 200 mg 20 pcs

Pharmacological action – antimicrobial, antiprotozoal, antifungal.

Pharmacodynamics

Nifuratel is an antimicrobial agent of nitrofuran group with antiprotozoal, antifungal and antibacterial action.

Nifuratel has high efficacy and low toxicity which leads to a wide range of its clinical use.

Highly effective against Papiliobacter and Helicobacter pylori, Gram-positive and Gram-negative microorganisms.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteridis, Klebsiella spp, Enterobacter spp., Serratia spp., Citrobacter spp, Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (trichomonads, amebas, giardia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa. It is the drug of choice for the treatment of salmonellosis, shigellosis and other acute intestinal bacterial infections.

It is active against Trichomonas vaginalis, highly active against fungi of the genus Candida.

Particularly effective against strains of Helicobacter pylori resistant to metronidazole.

Pharmacokinetics

In oral administration it is quickly absorbed from the gastrointestinal tract. It penetrates through the GEB and GPB and is excreted with breast milk. It is metabolized in the liver and muscle tissue. It is completely excreted by the kidneys (30-50% unchanged), having a strong antibacterial effect in the urinary tract.

Indications

Vulvovaginal infections caused by pathogens sensitive to the drug (pathogenic microorganisms, Candida fungi, Trichomonas, bacteria, chlamydia).
Pyelonephritis, urethritis, cystitis, pyelitis and other diseases of the urinary system.
Intestinal amebiasis and giardiasis.
Chronic inflammatory diseases of the upper gastrointestinal tract associated with Helicobacter pylori infection.

Pharmacological effect

Pharmacological action – antimicrobial, antiprotozoal, antifungal.

Pharmacodynamics

Nifuratel is an antimicrobial agent from the nitrofuran group, has antiprotozoal, antifungal and antibacterial effects.

Nifuratel has high efficiency and low toxicity, which determines a wide range of its clinical use.

Highly effective against Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteridis, Klebsiella spp., Enterobacter spp., Serratia spp., Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobacteria, as well as protozoa (Trichomonas, amoebas, Giardia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa. It is the drug of choice for the treatment of salmonellosis, shigellosis and other acute intestinal bacterial infections.

Active against Trichomonas vaginalis, highly active against fungi of the genus Candida.

Particularly effective against Helicobacter pylori strains resistant to metronidazole.

Pharmacokinetics

When taken orally, it is quickly absorbed from the gastrointestinal tract. Penetrates through the BBB and GPB and is excreted in breast milk. Metabolized in the liver and muscle tissue. It is completely excreted from the body by the kidneys (30–50% unchanged), providing a strong antibacterial effect in the urinary tract.

Special instructions

When treating vaginal infections only with oral therapy with Nifuratel-SZ, it is recommended to increase the daily dosage of the drug to 4-6 tablets.
During the treatment period you should abstain from sexual intercourse.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles or engage in potentially hazardous activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Nifuratel

Composition

1 tablet contains:

active ingredient:

nifuratel – 200 mg;

excipients: corn starch – 90.7 mg, gelatin -2.3 mg, polyethylene glycol 6000 (macrogol) – 15.0 mg, talc – 9.0 mg; magnesium stearate – 3.0 mg;

shell composition: hypromellose – 5.37 mg, polysorbate-80 (Tween-80) – 1.50 mg, talc – 1.50 mg, titanium dioxide E 171 – 1.13 mg, aluminum varnish based on quinoline yellow dye – 0.50 mg.

Pregnancy

Pregnancy

When administered orally, Nufuratel does not have a teratogenic effect in preclinical studies in mice, rats and rabbits.

There are no clinical studies in pregnant women. It is not recommended to use the drug during pregnancy. The drug should be prescribed only under the supervision of a physician after careful evaluation of the benefits versus the possible risks.

Nifuratel penetrates through the GPB, so the use of the drug is possible only under strict indications, if the expected effect of therapy for the mother exceeds the potential risk to the fetus. If you suspect pregnancy, it is recommended to consult a doctor.

Breast-feeding

Nifuratel is excreted into breast milk, therefore, if it is necessary to prescribe the drug during breastfeeding, the issue of stopping breastfeeding should be decided.

Contraindications

Hypersensitivity to the active substance or any component of the drug.

Children under 3 years of age and weighing less than 20 kg.

Side Effects

Dyspeptic disorders: nausea, vomiting, bitterness in the mouth, diarrhea, heartburn.

Allergic reactions: skin rash, itching.

Interaction

Strengthens the antifungal effect of nystatin.

Overdose

There have been no cases of overdose.

Storage conditions

In a place protected from light, at a temperature not exceeding 25 °C.

Keep out of the reach of children.

Shelf life

3 years. Do not use after the expiration date stated on the package.

Manufacturer

North Star NAO, Russia