Nicorette Fruit, 4 mg 20 pcs.

H-cholinomimetic. An alkaloid found in the leaves of tobacco (Nicotiana tabacum and Nicotiana rustica) and some other plants. It affects peripheral and central n-cholinoreceptors. The most sensitive to nicotine are the n-cholinoreceptors of the autonomic ganglia, on which nicotine has a biphasic effect. The excitation phase is characterized by depolarization of ganglionic neurons membranes, the inhibition phase is due to competitive antagonism with acetylcholine.

Nicotine stimulates chemoreceptors of sinocarotid zone, which is accompanied by reflex excitation of respiratory and vasomotor centers. The phase of inhibition is observed in case of significant amount of nicotine accumulation in blood.

In low doses nicotine excites n-cholinoreceptors of adrenal chromaffin cells and therefore increases adrenaline release into blood. In high doses nicotine causes the opposite effect.
At doses much higher than those required to influence the autonomic ganglia, nicotine first facilitates and then inhibits neuromuscular transmission.

In the action of nicotine on synaptic transmission in the CNS there is also a biphase: in low doses the substance causes an excitatory effect, in high – inhibitory.

HR after nicotine injection first slows down (excitation of vagus nerve center and intramural parasympathetic ganglia), then it increases (stimulation of sympathetic ganglia and increase in adrenaline by chromaffin cells).

Nicotine in low doses increases BP due to excitation of sympathetic ganglia and the vasomotor center, increased adrenaline release by the adrenal medullary layer and direct myotropic vasoconstrictor effect.

The effect of nicotine is often manifested by nausea (central origin), sometimes vomiting. Intestinal motility nicotine increases. Salivary and bronchial gland secretion is initially increased, followed by inhibition.

Pharmacokinetics

It is well absorbed from mucous membranes. Binding of nicotine with plasma proteins is less than 5%. Metabolism of nicotine occurs mainly in liver, also metabolized in kidneys and lungs. Passes through the BBB. It is excreted with breast milk. T1/2 is 2-3 hours. 10-30% of nicotine dose is excreted unchanged by the kidneys.

Indications

Composition

How to take, the dosage

Interaction

Special Instructions

Contraindications