Neurodiklovit, 30 pcs.

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Composition

One capsule contains:

Active ingredients:

Auxiliary substances:

Povidone K 25 8.42 mg,

Methacrylic acid and ethyl acrylate copolymer (1 : 1) 30% dispersion 5.60 mg,

Triethylcitrate 0.60 mg, talc 3.08 mg.

Capsule shell: case:

titanium dioxide (E 171) 0.9240 mg,

iron oxide red dye (E 172) 0.0061 mg,

iron oxide yellow dye (E 172) 0.0924 mg,

gelatin 45.1775 mg.

How to take, the dosage

Overly, with meals, without chewing, drinking plenty of fluids.

Adults: 1 capful 3 times a day at the beginning of treatment, 1-2 times a day as a maintenance dose.

The duration of therapy depends on the nature and severity of the disease.

Adults Neurodiklovit is prescribed 1 capsule 3 times a day in the beginning of treatment and 1 to 2 times a day as a maintenance dose.

The duration of therapy depends on the nature and severity of the disease.

Interaction

The drug increases the plasma concentration of digoxin, methotrexate, lithium drugs and cyclosporine.

Decreases the effect of diuretics, against potassium-saving diuretics the risk of hyperkalemia increases; against anticoagulants, thrombolytic agents (alteplase, streptokinase, urokinase) – risk of bleeding (often from the gastrointestinal tract).

Limits the effects of hypotensive and sleeping pills.

Induces side effects of other NSAIDs and glucocorticosteroids (gastrointestinal bleeding), methotrexate toxicity and cyclosporine nephrotoxicity.

Acetylsalicylic acid reduces the blood concentration of diclofenac.

Concomitant use with paracetamol increases the risk of nephrotoxic effects of diclofenac.

Decreases the effect of hypoglycemic agents.

Cefamandole, cefoperazone, cefotetan, valproic acid and plikamycin increase the incidence of hypoprothrombinemia.

Cyclosporine and gold drugs increase the effect of diclofenac on prostaglandin synthesis in the kidneys, which increases nephrotoxicity.

Concomitant use with ethanol, colchicine, corticotropin, serotonin reuptake inhibitors and St John’s wort preparations increases the risk of gastrointestinal bleeding.

Diclofenac increases the effect of drugs that cause photosensitization.

Antibacterial drugs from the quinolone group – risk of seizures.

Drugs that block tubular secretion increase the plasma concentration of diclofenac, thereby increasing its toxicity.

The drug reduces the antiparkinsonian effectiveness of levodopa.

Ethanol sharply reduces absorption of thiamine (blood levels may decrease by 30%). Prolonged treatment with anticonvulsants can lead to thiamine deficiency. The use of colchicine and biguanides reduces absorption of cyanocobalamin. While taking the drug, it is not recommended to take multivitamin complexes that include B vitamins.

Special Instructions

Patients taking the drug should refrain from activities that require increased attention and rapid mental and motor reactions, and alcohol consumption.

Contraindications

Side effects

Allergic reactions, diarrhea, nausea, headache are possible.

Overdose

Symptoms: vomiting, gastrointestinal tract (GIT) bleeding, epigastric pain, diarrhea, dizziness, tinnitus, lethargy, seizures; rarely – increased blood pressure, acute renal failure, hepatotoxic effect, respiratory depression, coma.

Treatment: gastric lavage, activated charcoal, symptomatic therapy aimed at eliminating increased blood pressure, impaired renal function, seizures, gastrointestinal irritation, respiratory depression.

Forced diuresis, hemodialysis are ineffective (due to significant binding to proteins and intense metabolism).

Pregnancy use

Neurodiklovit is not recommended for children under 18 years of age, pregnant women and during lactation.