Nesopin, spray 0.05% 20 ml

Stimulates alpha-adrenoceptors: in low concentrations it has mainly α2-adrenomimetic effect, in high concentrations it also acts on α1-adrenoceptors.

Constriction of vessels at the site of application. When administered intranasally it reduces swelling of the mucous membrane of the upper airways, facilitates nasal breathing, reduces blood flow to the venous sinuses. When injected into the conjunctival sac it reduces conjunctival edema.

The action starts 15 minutes after application; its duration is 6-8 hours.

Pharmacokinetics

In topical administration (spray) oxymetazoline undergoes little systemic absorption, so its concentration in blood plasma is negligible.

It is mainly excreted unchanged in the urine and feces. T1/2 is 5-8 days.

Indications

Acute rhinitis (including allergic), vasomotor rhinitis, paranasal sinusitis, eustachitis, otitis media; for mucosal narrowing for diagnostic purposes (under medical supervision).

Active ingredient

Composition

Active ingredient:

Oxymetazoline hydrochloride – 0.5 mg;

Auxiliary substances:

Menthol,

Eucalyptus oil,

dinatrium edetate,

diyatrium hydrophosphate dodecahydrate,

sodium dihydrophosphate dihydrate,

propylene glycol,

benzyl alcohol,

water for injection up to 1 ml.

How to take, the dosage

Nesopin is administered intranasally.

Adults and children over 12 years of age – 2-3 injections into each nasal passage at intervals of 10-12 hours.

In children 6 to 12 years of age, 1 injection in each nasal passage.

Interaction

Delays absorption of local anesthetic drugs, prolongs their effect.

The co-administration of other vasoconstrictor drugs increases the risk of side effects.

Concomitant administration of monoamine oxidase blockers and tricyclic antidepressants increases blood pressure.

Special Instructions

In the recommended dosage without consulting a doctor, it can be used for no more than 3 days.

Avoid contact of the drug intended for intranasal administration with the eyes.

The drug has an effect on vision (in case of contact with the eyes), reduction of reaction speed is possible.

In dosages higher than recommended, may affect the ability to operate vehicles or equipment.

Contraindications

With caution, the drug should be used in patients with chronic heart failure, arrhythmia, significant atherosclerosis, arterial hypertension, thyrotoxicosis, diabetes, chronic renal failure, closed-angle glaucoma.

Side effects

Local reactions: transient dryness and burning of the nasal mucosa, dry mouth and throat, sneezing. With long-term use – tachyphylaxis, reactive mucosal hyperemia and atrophy of the nasal mucosa.

Systemic reactions: increased BP, increased anxiety, nausea, dizziness, headache, insomnia, palpitations, sleep disturbances.

Overdose

Symptoms: tachycardia, increased blood pressure, central nervous system depression.

Treatment: symptomatic.

Pregnancy use

The drug is contraindicated in pregnancy and during breastfeeding.

Similarities