Mydocalm-Richter, 100 mg+2, 5 mg/ml 1 ml 5 pcs

Midocalm is a myorelaxant.

Pharmacodynamics

Myorelaxant of central action. The mechanism of action is not fully elucidated. It has membrane stabilizing and local anesthetic effect, inhibits conduction of impulses in primary afferent fibers and motor neurons which leads to blocking of spinal mono- and polysynaptic reflexes.

It also probably secondary inhibits mediator release by inhibiting Ca²⁺ entry into synapses. In the brainstem, it eliminates the facilitation of excitation conduction along the reticulospinal pathway.

It enhances peripheral blood flow independent of CNS influence. The weak antispasmodic and adrenoblocking effect of tolperisone plays a role in the development of this effect.

Pharmacokinetics

Tolperisone is well absorbed from the gastrointestinal tract after oral administration. C_max is reached after 0.5-1 h, bioavailability is about 20%.

Tolperisone is metabolized in the liver and kidneys. It is excreted in the urine as metabolites (more than 99%). The pharmacological activity of the metabolites is unknown.

Indications

Composition

Active ingredients:

Tolperisone hydrochloride 100 mg,

Lidocaine hydrochloride 2.5 mg;

Associates:

methylparaben,

diethylene glycol monoethyl ether,

water d/i;

How to take, the dosage

Injected in adults in m/m 100 mg twice a day or intravenously (slowly) 100 mg once a day.

Interaction

Special Instructions

Contraindications

Side effects

Muscular weakness, headache, arterial hypotension, nausea, vomiting, abdominal discomfort. When the dose is reduced, the side effects usually go away.

In rare cases, allergic reactions (skin itching, erythema, urticaria, angioedema, anaphylactic shock, bronchospasm) occur.

Overdose