Minisan Vitamin D3 tablets, 5 mcg 100 pcs

Minisan Vitamin D3 is a remedy to compensate for vitamin D3 deficiency. It participates in the regulation of calcium-phosphorus exchange, increases the absorption of calcium and phosphate in the intestine (due to increased permeability of cell and mitochondrial membranes of the intestinal epithelium) and their reabsorption in renal tubules; promotes bone mineralization, formation of bone skeleton and teeth in children, increases the ossification process, necessary for normal functioning of parathyroid glands.

Pharmacokinetics

Absorption is fast (in the distal small intestine), enters the lymphatic system, enters the liver and the general bloodstream. In the blood it binds with alpha2-globulins and partially with albumin. It accumulates in the liver, bones, skeletal muscles, kidneys, adrenal glands, myocardium and adipose tissue.

The time of reaching Cmax in tissues is 4-5 hours, then the concentration of colecalciferol decreases and remains constant for a long time. In the form of polar metabolites it is localized mainly in cell membranes, microsomes, mitochondria and nuclei. It penetrates the placental barrier and is excreted with breast milk. It is deposited in the liver.

It is metabolized in liver and kidneys: in liver it is transformed into inactive metabolite calcifediol (25-dihydrocolecalciferol), in kidneys it is transformed from calcifediol into active metabolite calcitriol (1,25-dihydroxycolecalciferol) and inactive metabolite 24,25-dihydroxycolecalcifediferol. It is subject to intestinal-hepatic recirculation.

Vitamin D3 and its metabolites are excreted in the bile, a small amount by the kidneys.

Form of release

Pills