Minisan Vitamin D3 tablets, 5 mcg 100 pcs

Minisan Vitamin D3 is a remedy to compensate for vitamin D3 deficiency. It participates in the regulation of calcium-phosphorus exchange, increases the absorption of calcium and phosphate in the intestine (due to increased permeability of cell and mitochondrial membranes of the intestinal epithelium) and their reabsorption in renal tubules; promotes bone mineralization, formation of bone skeleton and teeth in children, increases the ossification process, necessary for normal functioning of parathyroid glands.

Pharmacokinetics

Absorption is fast (in the distal small intestine), enters the lymphatic system, enters the liver and the general bloodstream. In the blood it binds with alpha2-globulins and partially with albumin. It accumulates in the liver, bones, skeletal muscles, kidneys, adrenal glands, myocardium and adipose tissue.

The time of reaching Cmax in tissues is 4-5 hours, then the concentration of colecalciferol decreases and remains constant for a long time. In the form of polar metabolites it is localized mainly in cell membranes, microsomes, mitochondria and nuclei. It penetrates the placental barrier and is excreted with breast milk. It is deposited in the liver.

It is metabolized in liver and kidneys: in liver it is transformed into inactive metabolite calcifediol (25-dihydrocolecalciferol), in kidneys it is transformed from calcifediol into active metabolite calcitriol (1,25-dihydroxycolecalciferol) and inactive metabolite 24,25-dihydroxycolecalcifediferol. It is subject to intestinal-hepatic recirculation.

Vitamin D3 and its metabolites are excreted in the bile, a small amount by the kidneys.

Indications

Composition

One tablet of Minisan® Vitamin D3 contains 5 µg (200 IU) or 20 µg (800 IU) of fat-soluble vitamin D3.

Sorbitol (sweetener), xylitol (sweetener), vitamin D3 complex (gum arabic (carrier), sucrose, corn starch, medium-chain triglycerides, vitamin D3, alpha-tocopherol (antioxidant), magnesium stearate (glazer).

How to take, the dosage

The recommended daily dose is 1 tablet of Minisan Vitamin D3.

Interaction

The risk of hypercalcemia is increased by thiazide diuretics.

In hypervitaminosis D3 there may be increased effect of cardiac glycosides and increased risk of arrhythmias due to the development of hypercalcemia (monitoring of blood calcium concentration, electrocardiogram, and correction of cardiac glycoside dose is advisable).

Under the influence of barbiturates (including phenobarbital), phenytoin and primidone the need for colocalciferol may increase significantly (increase the metabolic rate).

Long-term therapy with concomitant use of aluminum- and magnesium-containing antacids increases their concentrations in the blood and the risk of intoxication (especially in the presence of chronic renal failure).

Calcitonin, bisphosphonates, plycamycin, gallium nitrate and GCS reduce the effect of the drug.

Colestyramine, colestipol, and mineral oils decrease gastrointestinal absorption of fat-soluble vitamins and require increasing their dose.

Adds absorption of phosphorus-containing drugs and the risk of hyperphosphatemia.

In concomitant use with sodium fluoride, the interval between doses should be at least 2 h; with oral forms of Hetracycline at least 3 h.

Simultaneous use with other analogues of vitamin D3 increases the risk of hypervitaminosis.

The concomitant use of benzodiazepines increases the risk of hypercalcemia.

Isoniazid and rifamycin can decrease the effect of the drug due to increased biotransformation rate.

It does not interact with food.

Contraindications

With caution: Atherosclerosis, heart failure, renal failure, pulmonary tuberculosis (active form), sarcoidosis or other granulomatosis, hyperphosphatemia, phosphate nephrourolithiasis, organic heart disease, acute and chronic liver and kidney disease, GI diseases, gastric and duodenal ulcers, pregnancy, lactation, hypothyroidism.

Overdose

Symptoms of vitamin D3 hypervitaminosis:

Symptoms of chronic vitamin D3 intoxication (when taken for several weeks or months for adults at doses of 20000-60000 IU/day, children 2000-4000 IU/day):

Treatment: drug withdrawal, low-calcium diet, large fluid intake, GCS administration, in severe cases intravenous administration of 0.9% sodium chloride solution, furosemide, electrolytes, calcitonin, hemodialysis. The specific antidote is unknown.

In order to prevent overdose in a number of cases it is recommended to control the concentration of calcium in the blood.