Migrenium, 65 mg+500 mg 20 pcs.

Mygrenium is a combined preparation, the effect of which is determined by the components in its composition.

Caffeine has psychostimulant (it stimulates psychomotor centers of the brain), analeptic effect, enhances the effect of analgesics, eliminates sleepiness and fatigue, increases physical and mental performance. It affects the cardiovascular system: it increases the heart rate and heart rate (HR), increases blood pressure (BP) in hypotension (it does not change the normal blood pressure). Dilates bronchi, biliary tracts, blood vessels of skeletal muscles, heart, kidneys, narrows vessels of abdominal organs. Reduces platelet aggregation. It stimulates secretion of gastric glands, increases basic metabolism, has a moderate diuretic effect.

Paracetamol has antipyretic and analgesic effect (due to inhibition of cyclooxygenase (COX) and inhibition of prostaglandin synthesis (Pg), it affects the thermoregulation center in hypothalamus and conduction of pain impulses in the central nervous system (CNS). The drug blocks cyclooxygenase I and II mainly in the CNS, affecting the centers of pain and thermoregulation. In inflamed tissues cellular peroxidases neutralize the effect of paracetamol on cyclooxygenase, which explains its almost complete lack of anti-inflammatory effect.

The drug has no negative effect on water-salt metabolism (sodium and water retention) and gastrointestinal (GI) mucosa due to no effect on prostaglandin synthesis in peripheral tissues. The possibility of formation of methemoglobin is unlikely.

Pharmacokinetics

Caffeine and its water-soluble salts are well absorbed in intestine (including large intestine). Period of semi-elimination of the drug (T1/2) is about 5 hours, in some patients – up to 10 hours. The main part is demethylated and oxidized. About 10% is excreted unchanged by the kidneys.

Paracetamol is quickly and almost completely absorbed from the gastrointestinal tract. Plasma concentrations reach a peak after 30-60 minutes. Plasma T1/2 is 1-4 hours. It is metabolized in the liver. It is excreted in the urine, mainly as esters with glucuronic and sulfuric acids; less than 5% is excreted unchanged.