Mezim forte, 80 pcs.

Pharmacotherapeutic group: digestive enzyme agent

ATX code: A09AA02

Pharmacological properties

Pancreatin is a powder from the pancreas of pigs.

Pancreatic enzymes (lipase, amylase, protease) have proteolytic, amylolytic and lipolytic effects and contribute to the breakdown of proteins, fats, carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing the digestive processes. It is assumed to inhibit active trypsin by feedback type of stimulated pancreatic secretion in the upper part of the small intestine. Analgesic effect of pancreatin preparations described in some cases is attributed to this effect. Pancreatic enzymes are not absorbed in the gastrointestinal tract and are excreted through the intestine, most of them being denatured by digestive juices.

Indications

Violations of the enzymatic (exocrine) function of the pancreas in diseases of the gastrointestinal tract accompanied by digestive disorders.
To improve food digestion in patients with normal gastrointestinal function with dietary errors.

Pharmacological effect

Pharmacotherapeutic group: digestive enzyme agent

ATX code: A09AA02

Pharmacological properties

Pancreatin is a powder made from porcine pancreas.

Pancreatic enzymes (lipase, amylase, protease) have proteolytic, amylolytic and lipolytic effects and promote the breakdown of proteins, fats, carbohydrates, improve the functional state of the gastrointestinal tract (GIT), thus normalizing digestive processes. It is assumed that active trypsin inhibits stimulated pancreatic secretion in the upper part of the small intestine by feedback. The analgesic effect of pancreatin preparations, described in some cases, is associated with this effect. Pancreatic enzymes are not absorbed in the gastrointestinal tract, they are excreted through the intestines, most of them are denatured under the influence of digestive juices.

Special instructions

The drug Mezim® forte contains active enzymes that, when released in the oral cavity, for example during chewing, can damage the oral mucosa (up to the formation of ulcers). Therefore, the tablet must be swallowed whole.

Impact on the ability to drive vehicles and other mechanisms

The drug Mezim® forte does not affect or has an insignificant effect on the ability to drive vehicles and machines.

Active ingredient

Pancreatin

Composition

1 film-coated tablet contains:

Core:

Active ingredient:
Pancreatin* – 116.66 – 134.61 mg with minimal activity:

lipase – 3500 units Ph.Eur.
amylase 4200 IU Рh.Еur.
protease 250 IU Рh.Еur.

Excipients: microcrystalline cellulose (type 12), sodium carboxymethyl starch (type A), colloidal anhydrous silicon dioxide, magnesium stearate.

Shell: talc, hypromellose, azorubine dye (E 122), simethicone emulsion 30% (dry weight), polyacrylate dispersion 30% (dry weight), titanium dioxide (E 171), macrogol 6000.
*obtained from pork pancreas

Pregnancy

There are no data on the use of pancreatin during pregnancy and breastfeeding.
During pregnancy and breastfeeding, the prescription of pancreatin by the attending physician is possible only if the expected benefit to the mother outweighs the possible risk to the fetus or child.

Contraindications

hypersensitivity to any of the components of the drug.
acute pancreatitis or exacerbation of chronic pancreatitis. However, it is possible to use it in the phase of a fading exacerbation when expanding the diet, if there are signs of digestive disorders;
children up to 3 years of age (for this dosage form).

Side Effects

Possible side effects are listed below in descending frequency of occurrence: very common (≥ 1/10), common (≥ 1/100, < 1/10), uncommon (≥ 1/1000, < 1/100), rare (≥ 1/10000, < 1/1000), very rare (< 1/10000), frequency unknown (estimate based on available data) impossible).

Immune system disorders
Very rare: immediate allergic reactions.
Frequency unknown: allergic reactions to the components of the drug are possible (see section “Composition”).

Gastrointestinal disorders
Very rare: gastrointestinal hypersensitivity (eg, diarrhea, epigastric discomfort, nausea).

Interaction

The absorption of folic acid may be reduced, which may require additional intake when used simultaneously with pancreatin. The effect of hypoglycemic agents for oral administration (acarbose, miglitol) may be reduced when used simultaneously with drugs containing digestive enzymes that break down carbohydrates (for example, amylase).

Overdose

No cases of overdose have been reported.

Storage conditions

At a temperature not exceeding 25 °C.
Keep out of the reach of children!

Shelf life

3 years. Do not use after expiration date.

Organization receiving complaints from consumers:

LLC “Berlin-Chemie/A. Menarini”, Russia

123112, Moscow, Presnenskaya embankment, building 10, Business Center “Tower on the Embankment”, Block B, tel. (495) 785-01-00, fax (495) 785-01-01.

Manufacturer

Berlin-Chemie AG, Germany