Mexidol Forte 250,250 mg 40 pcs

Mexidol^® Forte 250 is an inhibitor of free radical processes, membranoprotector with antihypoxic, stress-protective, nootropic, antiepileptic and anxiolytic action. It belongs to the class of 3-oxypyridines.

The mechanism of action of the drug Mexidol ^® Forte 250 is due to its antioxidant, antihypoxant and membrane-protective action. The drug inhibits lipid peroxidation, increases superoxide dismutase activity, increases lipid-protein ratio, improves cell membrane structure and function. Mexidol^® Forte 250 modulates the activity of membrane-bound enzymes (calcium-independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine) that increase their ability to bind to ligands, maintain the structural and functional organization of biomembranes, transport neurotransmitters and improve synaptic transmission. Mexidol^® Forte 250 increases dopamine content in the brain. Increases compensatory activation of aerobic glycolysis and decreases the degree of inhibition of oxidative processes in the Krebs cycle in hypoxia with increase of ATP and creatine phosphate, activation of energy-synthesizing functions of mitochondria.

Enhances resistance of the body to various damaging factors in pathological conditions (hypoxia and ischemia, impaired cerebral circulation, intoxication with ethanol and antipsychotic drugs).

In conditions of critical reduction of coronary blood flow promotes the preservation of structural and functional organization of cardiomyocyte membranes, stimulates the activity of membrane enzymes – phosphodiesterase, adenylate cyclase, acetylcholinesterase. It supports activation of aerobic glycolysis developing in acute ischemia and promotes under hypoxia restoration of mitochondrial redox processes, increases ATP and creatine phosphate synthesis. Ensures the integrity of morphological structures and physiological functions of ischemic myocardium. Improves the clinical course of myocardial infarction, increases the effectiveness of therapy, reduces the incidence of arrhythmias and intracardiac conduction abnormalities. Normalizes metabolic processes in ischemic myocardium, increases antianginal activity of nitrates, improves rheological properties of blood, reduces consequences of reperfusion syndrome in acute coronary failure.

Limits enzymatic toxemia and endogenous intoxication in acute pancreatitis.

It improves metabolism and blood supply of the brain, improves microcirculation and rheological properties of the blood, reduces platelet aggregation. It stabilizes membrane structures of blood cells (erythrocytes and platelets), reducing the likelihood of hemolysis. It has hypolipidemic effect, reduces the content of total cholesterol and LDL.

The anti-stressor effect is shown in normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, disturbed learning and memory processes, decrease of dystrophic and morphological changes in different structures of the brain.

Mexidol ^® Forte 250 has a marked anti-toxic effect in withdrawal syndrome. It eliminates neurological and neurotoxic symptoms of acute alcohol intoxication, restores behavioral disorders, vegetative functions and is also able to relieve cognitive disorders caused by prolonged use of ethanol and its withdrawal. Under the influence of the drug the effect of tranquilizing drugs, neuroleptics, antidepressants, hypnotics and anticonvulsants increases, which allows reducing their doses and side effects.

The Mexidol^® Forte 250 improves the functional state of the ischemic myocardium. In conditions of coronary insufficiency it increases collateral blood supply to the ischemic myocardium, helps to preserve the integrity of cardiomyocytes and maintain their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.

Indications

The drug Mexidol® FORTE 250 is used in adults over 18 years of age:
in the consequences of acute cerebrovascular accidents, including after transient disturbances in the blood supply to the brain (transient ischemic attacks), in the initial stage of the disease (in the subcompensation phase) as preventive courses;
with mild traumatic brain injury, consequences of traumatic brain injury;
for disorders of the brain (encephalopathies) of various origins (caused by circulatory disorders (dyscirculatory), metabolic disorders (dysmetabolic), post-traumatic, mixed);
in case of circulatory disorders (chronic ischemia) of the brain;
in a condition caused by a malfunction of the nerves that control the functions of internal organs (vegetative dystonia syndrome);
with a decrease in memory, attention and mental performance (mild (moderate) cognitive disorders);
for anxiety disorders in neurotic and neurosis-like conditions;
for heart disease caused by insufficient blood supply (coronary heart disease) as part of complex therapy;
with a complex of complaints that arise after an abrupt cessation of alcohol consumption (withdrawal syndrome) with alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, delayed painful manifestations of an abrupt cessation of alcohol consumption (post-withdrawal disorders);
in a condition after acute poisoning (intoxication) with drugs for the treatment of mental illnesses (antipsychotics);
in weakened conditions with increased fatigue (asthenic conditions), as well as for the prevention of the development of diseases of internal organs (somatic diseases) under the influence of extreme factors and stress;
when exposed to extreme (stress) factors.

Pharmacological effect

Mexidol® FORTE 250 increases the body’s resistance to various damaging factors during shock, insufficient oxygen supply to tissues (hypoxia) and insufficient blood supply to tissues (ischemia), cerebrovascular accidents, alcohol poisoning and antipsychotic drugs (neuroleptics). Mexidol® FORTE 250 is able to neutralize reactive oxygen species (free radicals) formed during the listed diseases, thereby reducing damage that could cause cell death in the body.
If there is no improvement or you feel worse, you should consult a doctor.

Special instructions

Before using Mexidol® FORTE 250, consult your doctor. Be sure to tell your doctor if you have an intolerance to certain sugars, because… the product contains lactose.

Children and teenagers

The use of the drug in children under 18 years of age is not recommended due to the lack of data on efficacy and safety.

Active ingredient

Ethylmethylhydroxypyridine succinate

Composition

Active ingredient: ethylmethylhydroxypyridine succinate

Pregnancy

If you are pregnant or breastfeeding, think you may be pregnant, or are planning a pregnancy, consult your doctor before using this medicine. Mexidol® FORTE 250 is contraindicated during pregnancy and breastfeeding.

Contraindications

Do not take Mexidol® FORTE 250:
if you are allergic to ethylmethylhydroxypyridine succinate or any of the other ingredients of this medicine (listed in section 6 of the leaflet);
if you have acute liver dysfunction;
if you have acute renal impairment;
if you are under 18 years of age;
if you are pregnant or breastfeeding;
if you are intolerant to certain sugars (the drug contains lactose).

Side Effects

Like all medicines, Mexidol® FORTE 250 can cause side effects, but not everyone gets them.
Call your doctor immediately if you feel that any of the following side effects are becoming serious. Call your doctor immediately if you experience any side effects not listed in this leaflet.

The following adverse reactions may occur

Very rare (occurrence in less than 1 person in 10,000):
a serious allergic reaction that may include difficulty breathing, swelling of the face, neck, lips, tongue, or throat (angioedema);
allergic itchy rash (urticaria);
drowsiness;
headache;
dry mouth;
nausea;
pain, burning and discomfort in the stomach (epigastric region);
heartburn;
increased accumulation of gases in the intestines (flatulence);
diarrhea;
rash;
itching;
redness of the skin (hyperemia).

Interaction

Tell your doctor if you are taking, have recently taken, or may start taking any other medications.
The drug Mexidol® FORTE 250 is combined with all drugs used to treat diseases of internal organs (somatic diseases).
It is important to tell your doctor if you are taking anti-anxiety and insomnia medications such as diazepam or midazolam (benzodiazepine drugs), antidepressants, anxiety medications such as phenibut (anxiolytics), drugs for

treatment of epilepsy and seizures, for example, valproate, lamotrigine (anticonvulsants) and antiparkinsonian drugs, since Mexidol® FORTE 250 may enhance their effect.

The drug Mexidol® FORTE 250 reduces the toxic effects of ethyl alcohol.

Overdose

If you take more Mexidol® FORTE 250 than you should, you may experience drowsiness or insomnia. Treatment, as a rule, is not required, since the symptoms disappear on their own within 24 hours. If symptoms are severe, consult your doctor to receive appropriate treatment.

Storage conditions

Keep the drug out of the reach of children and so that the child cannot see it.
Store the drug in a place protected from light, at a temperature not exceeding 25 °C.

Shelf life

Do not use the drug after the expiration date (shelf life) indicated on the package. The expiration date is the last day of the given month.

Manufacturer

ZiO-Zdorovye CJSC, Russia