Mexidol, 125 mg 50 pcs.
€12.34 €11.98
Mexidol® is an inhibitor of free radical processes, membranoprotector with antihypoxic, stress-protective, nootropic, anticonvulsant and anxiolytic effects. The preparation increases resistance to the effects of different damaging factors (shock, hypoxia and ischemia, cerebral circulation disorders, intoxication with alcohol and antipsychotic drugs (neuroleptics).
Mexidol® action mechanism is based on its antioxidant, antihypoxant and membranoprotective actions. It inhibits lipid peroxidation, increases the activity of superoxide dismutase, increases the lipid-protein ratio, reduces membrane viscosity and increases its fluidity. Mexidol® modulates the activity of membrane-bound enzymes (calcium independent phosphodiesterase, adenylate cyclase, acetylcholinesterase), receptor complexes (benzodiazepine, GABA, acetylcholine), which increases their ability to bind to ligands, maintains structural and functional organization of biomembranes, transports neurotransmitters and improves synaptic transmission.
Mexidol® increases the content of dopamine in the brain. It causes enhancement of compensatory activation of aerobic glycolysis and reduction of the degree of inhibition of oxidative processes in the Krebs cycle under hypoxia with increase of ATP and creatine phosphate content, activation of energy-synthesizing functions of mitochondria and stabilization of cell membranes.
The drug improves metabolism and blood supply of the brain, improves microcirculation and blood rheology, reduces platelet aggregation. Stabilizes membrane structures of blood cells (erythrocytes and platelets) in hemolysis. It has hypolipidemic effect, reduces the content of total cholesterol and low-density lipoproteins.
The anti-stressor effect is shown in normalization of post-stress behavior, somatovegetative disorders, restoration of sleep-wake cycles, disturbed learning and memory processes, decrease of dystrophic and morphological changes in different structures of the brain.
Mexidol® has a pronounced anti-toxic effect during withdrawal syndrome. It eliminates neurological and neurotoxic manifestations of acute alcohol intoxication, restores disturbances of behavior, vegetative functions and is able to remove cognitive disorders caused by prolonged intake of ethanol and its withdrawal. Under the influence of Mexidol® the effects of tranquilizers, neuroleptics, antidepressants, hypnotics and anticonvulsants are increased, which allows reducing their dosages and side effects. Mexidol® improves functional state of ischemic myocardium. In conditions of coronary insufficiency it increases collateral blood supply of ischemic myocardium, promotes preservation of integrity of cardiomyocytes and maintenance of their functional activity. Effectively restores myocardial contractility in reversible cardiac dysfunction.
Pharmacokinetics
Intake
It is rapidly absorbed when taken orally. Maximum concentration at doses of 400 to 500 mg is 3.5 to 4.0 µg/mL.
Distribution
The drug is rapidly distributed in organs and tissues. Mean time of retention of the drug in the body when administered orally is 4.9 – 5.2 h. It is metabolized in the liver by glucuron conjugation. Five metabolites have been identified: 3-oxypyridine phosphate – formed in the liver and degraded to phosphoric acid and 3-oxypyridine with the assistance of alkaline phosphatase; the 2nd metabolite – pharmacologically active, formed in large amounts and found in the urine 1-2 days after administration; the 3rd – excreted in large amounts in the urine; the 4th and 5th – glucuron conjugates. T1/2 when administered orally is 2.0 – 2.6 h. </Excretion
Extracted rapidly in the urine mainly as metabolites and in insignificant amounts unchanged. Excretion is most intense during the first 4 hours after drug administration. Indexes of urinary excretion of unchanged drug and metabolites have individual variability.
Indications
The drug Mexidol® is used:
in the consequences of acute cerebrovascular accidents, including after transient disturbances in the blood supply to the brain (transient ischemic attacks), in the initial stage of the disease (in the subcompensation phase) as preventive courses;
with mild traumatic brain injury, consequences of traumatic brain injury;
for disorders of the brain (encephalopathies) of various origins (caused by circulatory disorders (dyscirculatory), metabolic disorders (dysmetabolic), post-traumatic, mixed);
in a condition caused by a malfunction of the nerves that control the functions of internal organs (vegetative dystonia syndrome);
with mild impairments of mental performance caused by vascular atherosclerosis (mild cognitive disorders of atherosclerotic origin);
for anxiety disorders in neurotic and neurosis-like conditions;
for heart disease caused by insufficient blood supply (coronary heart disease) as part of complex therapy;
with a complex of complaints that arise after an abrupt cessation of alcohol consumption (withdrawal syndrome), with alcoholism with a predominance of neurosis-like and vegetative-vascular disorders, delayed painful manifestations of an abrupt cessation of alcohol consumption (post-withdrawal disorders);
in conditions after acute poisoning (intoxication) with drugs for the treatment of mental illnesses (antipsychotics);
in weakened conditions with increased fatigue (asthenic conditions), as well as for the prevention of the development of diseases of internal organs (somatic diseases) under the influence of extreme factors and stress;
when exposed to extreme (stress) factors;
for attention deficit hyperactivity disorder in children, including hyperactivity, impaired attention, and impulsivity.
Pharmacological effect
Mexidol® increases the body’s resistance to various damaging factors during shock, insufficient oxygen supply to tissues (hypoxia) and insufficient blood supply to tissues (ischemia), cerebrovascular accidents, alcohol poisoning and antipsychotic drugs (neuroleptics). Mexidol® is able to neutralize reactive oxygen species (free radicals) formed during these diseases, thereby reducing damage that could cause cell death in the body. In children with hyperactivity and attention deficit, Mexidol® helps to increase concentration and ability to concentrate, increase perseverance, reduce signs of hyperactivity and reduce impulsivity, which helps improve learning and social adaptation of children.
If there is no improvement or you feel worse, you should consult a doctor.
Special instructions
Before using Mexidol®, consult your doctor. Be sure to tell your doctor if you have an intolerance to certain sugars, because… the product contains lactose.
Children and teenagers
The use of the drug in children under 6 years of age is not recommended due to the lack of data on efficacy and safety.
Driving vehicles and working with machinery
During the period of use of the drug, caution should be exercised when performing work that requires rapid psychophysical reactions (driving vehicles, machinery, etc.).
Active ingredient
Ethylmethylhydroxypyridine succinate
Composition
Active ingredient: ethylmethylhydroxypyridine succinate
Other ingredients (excipients) are lactose monohydrate, povidone K-30, magnesium stearate, film coating: hypromellose, titanium dioxide, lactose monohydrate, macrogol, triacetin.
Pregnancy
If you are pregnant or breastfeeding, think you may be pregnant, or are planning a pregnancy, consult your doctor before using this medicine. Mexidol® is contraindicated during pregnancy and breastfeeding.
Contraindications
Do not use Mexidol®:
if you are allergic to ethylmethylhydroxypyridine succinate or any of the other ingredients of this medicine (listed in section 6 of the leaflet);
if you have acute liver dysfunction;
if you have acute renal impairment;
the drug is contraindicated in children under 6 years of age;
if you are pregnant or breastfeeding;
if you are intolerant to certain sugars (the drug contains lactose).
Side Effects
Like all medicines, Mexidol® can cause side effects, but not everyone gets them.
Call your doctor immediately if you feel that any of the following side effects are becoming serious. Call your doctor immediately if you experience any side effects not listed in this leaflet.
The following undesirable reactions may occur:
Very rare (occurrence in less than 1 person in 10,000):
a serious allergic reaction that may include difficulty breathing, swelling of the face, neck, lips, tongue, or throat (angioedema);
allergic itchy rash (urticaria);
drowsiness;
headache;
dry mouth;
nausea;
pain, burning and discomfort in the stomach (epigastric region);
heartburn;
increased accumulation of gases in the intestines (flatulence);
diarrhea;
rash;
itching;
redness of the skin (hyperemia).
Interaction
Tell your doctor if you are taking, have recently taken, or may start taking any other medications.
The drug Mexidol® is combined with all drugs used to treat diseases of internal organs (somatic diseases).
It is important to tell your doctor if you are taking anti-anxiety and sleep medications such as diazepam or midazolam (benzodiazepine drugs), antidepressants, drugs to treat anxiety disorders such as phenibut (anxiolytics), drugs to treat epilepsy and seizures such as valproate, lamotrigine (anticonvulsants) and antiparkinsonian drugs, as the drug Mexidol® may enhance their effect.
The drug Mexidol® reduces the toxic effects of ethyl alcohol.
Overdose
If you take more Mexidol® than you should, you may experience drowsiness or insomnia. Treatment, as a rule, is not required, since the symptoms disappear on their own within 24 hours. If symptoms are severe, consult your doctor to receive appropriate treatment.
Storage conditions
Keep the drug out of the reach of children and so that the child cannot see it.
Store the drug in a place protected from light at a temperature not exceeding 25 °C.
Shelf life
Do not use the drug after the expiration date (shelf life) indicated on the package. The expiration date is the last day of the given month.
Manufacturer
ZiO-Zdorovye CJSC, Russia
Shelf life | 3 years |
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Conditions of storage | In a dry, light-protected place at a temperature not exceeding 25 °C |
Manufacturer | ZiO-Zdorovye CJSC, Russia |
Medication form | pills |
Brand | ZiO-Zdorovye CJSC |
Other forms…
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