Metadoxil, 300 mg/5 ml 5 ml 10 pcs

Metadoxyl – detoxifying, hepatoprotective, antialcoholic.

Pharmacodynamics

The hepatoprotective effect of metadoxin is due to membrane stabilizing effect and is based on the ability to restore the ratio of saturated and unsaturated free fatty acids. As a result, the resistance of hepatocytes to the action of lipid peroxidation, which occurs under the influence of various toxic agents, is increased. Metadoxin detoxifying effect is due to the activation of liver enzymes involved in the metabolism of ethanol – alcohol dehydrogenase and acetaldehyde dehydrogenase, which accelerates the elimination of ethanol and acetaldehyde from the body and thus reduces their toxic effects.

Metadoxin prevents accumulation of triglycerides in hepatocytes and also prevents formation of fibronectin and collagen, which significantly slows down the formation of cirrhosis.

The drug reduces mental and somatic manifestations of hangover syndrome, reduces the time of withdrawal syndrome relief.

Metadoxine activates cholinergic and GABAergic neurotransmitter systems, improves thinking and short-term memory functions, prevents motor agitation caused by ethanol.

Metadoxine has nonspecific antidepressant and anxiolytic effects, reduces craving for alcohol.

Pharmacokinetics

It is rapidly absorbed from the gastrointestinal tract and has high bioavailability (60-80%). Binding to plasma proteins is 50%. It is metabolized in liver to active metabolites – pyridine and pyrrolidone carboxylate. T1/2 is 40-60 min when administered orally or by parenteral injection. 45-50% of the drug is excreted in the urine within 24 hours, 35-50% of the drug is excreted in the feces within 96 hours.

Indications

Active ingredient

Composition

Active substance:

Metadoxin (pyridoxine L-2 pyrrolidone 5-carboxylate)300 mg;

Associates:

sodium metabisulfite;

sodium edetate;

methyl-p-hydroxybenzoate;

water for injection

How to take, the dosage

Acute alcohol intoxication: 300-600 mg (5-10 ml) in m/m or 300-900 mg (5-15 ml) in v/v, depending on the degree of intoxication.

In case of intravenous administration the required dose of the drug is diluted in 500 ml of isotonic sodium chloride solution or 5% dextrose (glucose) solution and administered by drip for 1.5 hours.

The complex therapy of liver diseases and chronic alcoholism: orally: 1 tablet 2 times a day (1000 mg) 15-30 minutes before a meal, the dose can be increased to 3 tablets (1500 mg) a day. The course of therapy should be at least 90 days.

Alcohol withdrawal syndrome: 900 mg (15 ml) as an IV infusion (see above) once a day for 3-7 days depending on the patient’s condition.

Interaction

When used together, it reduces the effectiveness of levodopa.

Contraindications

With caution: use with caution in Parkinson’s disease if levodopa is used at the same time, because methadoxine reduces the effectiveness of the drug.

The ampoules of the solution for injection contain sodium metabisulfite. This substance may cause allergic reactions or worsening of asthma attacks in predisposed people, especially those with bronchial asthma.

Side effects

Allergic reactions. Bronchial asthma patients may develop bronchospasm when using the solution for injection.

Pregnancy use

Metadoxil is contraindicated in pregnancy and lactation.