Magnesium Diaporal 300,5 g 20 pcs.

Pharmgroup:

Magnesium preparation.
Pharmaceutical action:

Magnesium is involved in most metabolic reactions, activates more than 300 enzymes. Irreplaceable element in the processes of energy supply and expenditure. It participates in the balance of electrolytes, ion transport, membrane permeability, in the regulation of nerve impulse transmission and in muscle contraction. It is a natural calcium antagonist.

Pharmacokinetics:

Magnesium is slowly and incompletely absorbed in the gastrointestinal tract and magnesium absorption is reduced with malabsorption syndrome and consumption of fat-rich foods. The unabsorbed part of magnesium is excreted through the intestine.

The serum contains about 1% of absorbed magnesium (0.8-1.0 mmol/L).About 45% of magnesium is bound to intracellular proteins and macroergic phosphates and is deposited in skeletal muscles, kidneys, liver, and myocardium. The remaining part is deposited in bone tissue; in small amounts in tissue fluid and erythrocytes.

Magnesium ions pass through the blood-brain barrier and the placental barrier.

Absorbed magnesium is eliminated by the kidneys, and only a small portion is excreted with the bile and through sweat glands. It is partially resorbed in the renal tubules. The rate of renal excretion is proportional to the plasma concentration and the value of glomerular filtration.

Indications

Magnesium deficiency accompanied by symptoms such as: slight sleep disturbances, increased irritability, mild anxiety, increased fatigue, cramps of the calf muscles.

Active ingredient

Composition

1 package:

– magnesium citrate 1.83 g (corresponding magnesium 295.7 mg)

How to take, the dosage

Ingestion.

Adults and children over 12 years of age take 1 sachet of Magnesium Dispensate 300 daily.

Dissolve the contents of 1 sachet in 0.5 cup of fruit juice, tea or water.

The treatment usually lasts for one month.

Interaction

Aminoglycoside antibiotics, cisplatin and cyclosporine accelerate magnesium excretion.

Magnesium ions, iron ions, fluorides and tetracycline mutually affect absorption of each other, so a 2-Z hour interval between administration of Magnesium-Diasporal 300 and drugs containing the above substances should be observed.

Magnesium weakens the effect of indirect anticoagulants and reduces iron absorption.

Special Instructions

The drug Magnesium-Diasporal 300 does not affect the ability to operate machines.

Contraindications

Individual hypersensitivity to the components of the drug Magnesium-Diasporal 300, severe renal failure, atrioventricular block, myasthenia, hypermagnesemia, children under 12 years of age.

Because of the presence of sucrose in the drug, Magnesium-Diasporal 300 is contraindicated if fructose intolerance, impaired glucose or galactose absorption syndrome, or deficiency of sucrose isomaltase.

With caution.

Moderate renal insufficiency (risk of hypermagnesemia).

Side effects

Allergic reactions, disorders of the gastrointestinal tract: diarrhea, abdominal pain, constipation, nausea, flatulence.

Overdose

Symptoms of overdose: decreased blood pressure, nausea, vomiting, slowed reflexes, respiratory depression, coma, cardiac arrest, anuria.

Treatment: Intravenous administration of calcium and intravenous or subcutaneous administration of 1-2 ampoules (0.5-1 mg/ml) of neostigmine methyl sulfate; intravenous or oral administration of 0.9% sodium chloride; in case of renal failure, hemodialysis or peritoneal dialysis.