Magnemax, tablets 500 mg 20 pcs

Magnesium preparation.

Magnesium is an essential trace element, is involved in more than 300 enzymatic reactions, the regulation of cellular permeability and neuromuscular excitability.

It is necessary for many energy processes, is involved in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the termination of cholinergic neurons, with a decrease in acetylcholine release.

Magnesium and calcium interact partially synergistically in the body: however, while competitively inhibiting calcium, magnesium can also affect binding sites as a physiological calcium antagonist.

Indications

Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as:

– increased fatigue;

– increased irritability;

– tingling sensation in the muscles.

– minor sleep disturbances;

– gastrointestinal spasms;

– pain and muscle spasms;

If after a month of treatment there is no improvement in these symptoms, continuing treatment is not advisable.

Pharmacological effect

Magnesium preparation.

Magnesium is an essential trace element; it is involved in more than 300 enzymatic reactions, regulation of cellular permeability and neuromuscular excitability.

Necessary for many energy processes, participates in the metabolism of proteins, fats, carbohydrates and nucleic acids. Magnesium has a curare-like effect on the terminals of cholinergic neurons, with a decrease in the release of acetylcholine.

Magnesium and calcium interact partially synergistically in the body: however, when competitively inhibiting calcium, magnesium can also act on binding sites as a physiological calcium antagonist.

Special instructions

The drug contains lactose monohydrate, therefore its use is not recommended for patients with hereditary galactosemia, glucose-galactose malabsorption syndrome and lactase deficiency.

Impact on the ability to drive vehicles and machinery

The drug does not affect the ability to drive vehicles, operate machinery or engage in other activities that require increased concentration and speed of psychomotor reactions.

Active ingredient

Magnesium orotate

Composition

1 tablet contains:

Contraindications

Hypersensitivity to the components of the drug;

urolithiasis;

renal dysfunction;

predisposition to the formation of calcium-magnesium-ammonium phosphate stones;

liver cirrhosis with ascites;

children under 18 years of age.

The drug contains lactose, so it should not be used in patients with lactose intolerance, lactase deficiency or glucose-galactose malabsorption.

Side Effects

From the gastrointestinal tract: unstable stool and diarrhea, which usually go away on their own when the dose of the drug is reduced.

From the immune system: allergic reactions.

Interaction

When taking magnesium-containing drugs simultaneously with iron, sodium fluoride and tetracyclines, absorption of the latter may decrease. In addition, aminoquinolines, quinidine, and penicillamine should not be administered simultaneously with magnesium preparations. Therefore, these drugs should be taken at intervals of 2-3 hours.

Oral contraceptives, diuretics, muscle relaxants, corticosteroids, insulin, reduce the effect of the drug.

Magnesium should be used with caution when taking magnesium-containing medications such as antacids or laxatives, or potassium-sparing diuretics or medications containing calcium.

When used simultaneously with drugs containing aluminum, the absorption of aluminum in the body may be increased.

Magnesium should be used with caution when used concomitantly with digitalis preparations as concurrent use may interfere with the absorption of digitalis preparations.

Some antibiotics (aminoglycosides), cisplatin and cyclosporine A may lead to increased excretion of magnesium.

Some diuretics (thiazides and furosemide), cetuximab and erlotinib, proton pump inhibitors (omeprazole and pantoprazole), foscarnet, pentamidine, rapamycin and amphotericin B may cause magnesium deficiency, and thus lead to a decrease in the effect of the drug.

Overdose

With normal kidney function, oral magnesium does not cause toxic reactions.

Magnesium poisoning can develop in kidney failure. Toxic effects mainly depend on serum magnesium concentration.

Symptoms: decreased blood pressure, nausea, vomiting, depression, slowed reflexes, respiratory depression, coma, cardiac arrest, anuric syndrome.

Treatment: rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.

Functional features

Approximately 35-40% of the dose taken is absorbed. Hypomagnesemia stimulates the absorption of magnesium ions. The presence of orotic acid salts improves the absorption of magnesium.

Magnesium is excreted by the kidneys; excretion decreases with magnesium deficiency and increases with its excess.

Storage conditions

The drug should be kept out of the reach of children
place at a temperature not exceeding 25°C.

Shelf life

3 years.

Manufacturer

Alium JSC, Russia