Magnelis B6, 120 pcs.
€23.85 €19.88
Pharmacotherapeutic group: Magnesium drug.
ATX code: A12CC01
Pharmacological properties
Compensates for magnesium deficiency.
Magnesium is a vital element that is found in all body tissues and is necessary for normal functioning of cells. It participates in most metabolic reactions, in the regulation of nerve impulse transmission and muscle contraction, has antispasmodic, antiarrhythmic and anti-aggregant effects.
The body gets magnesium with food. Lack of magnesium in the body may be observed in violation of diet (diet) or increased need for magnesium (with increased physical and mental stress, pregnancy, use of diuretics).
Pyridoxine (vitamin B6) is involved in many metabolic processes, in the regulation of metabolism of the nervous system. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
The serum magnesium content:
– 12 to 17 mg/L (0.5 to 0.7 mmol/L) indicates moderate magnesium deficiency.
– below 12 mg/L (0.5 mmol/L) indicates severe magnesium deficiency.
Pharmacokinetics
The absorption of magnesium in the gastrointestinal tract is 50% of the oral dose. It is excreted mainly through the kidneys. In the kidneys, after glomerular filtration of 70% of the magnesium present in plasma, it is reabsorbed by the renal tubules in the proportion of 95% – 97%.
Indications
Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as: increased irritability; minor sleep disturbances; gastrointestinal cramps; rapid heartbeat; increased fatigue; pain and muscle spasms, tingling sensation in the muscles.
Pharmacological effect
Pharmacotherapeutic group: Magnesium drug.
ATX code: A12CC01
Pharmacological properties
Replenishes magnesium deficiency.
Magnesium is a vital element that is found in all tissues of the body and is necessary for the normal functioning of cells. Participates in most metabolic reactions, in the regulation of the transmission of nerve impulses and in muscle contraction, and has antispasmodic, antiarrhythmic and antiplatelet effects.
The body receives magnesium through food. A lack of magnesium in the body can occur when the diet is disrupted or when the need for magnesium increases (with increased physical and mental stress, stress, pregnancy, use of diuretics).
Pyridoxine (vitamin B6) is involved in many metabolic processes and in the regulation of nervous system metabolism. Vitamin B6 improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium content:
– from 12 to 17 mg/l (0.5-0.7 mmol/l) indicates moderate magnesium deficiency.
– below 12 mg/l (0.5 mmol/l) indicates severe magnesium deficiency.
Pharmacokinetics
Absorption of magnesium in the gastrointestinal tract is 50% of the dose taken orally. It is excreted primarily through the kidneys. In the kidneys, after glomerular filtration of 70% of the magnesium present in the plasma, it is reabsorbed by the renal tubules in a proportion of 95% – 97%.
Special instructions
Information for patients with diabetes: tablets contain sucrose as an excipient.
In case of concomitant calcium deficiency, magnesium deficiency should be corrected before taking calcium supplements.
With frequent use of laxatives, alcohol, intense physical and mental stress, the need for magnesium increases, which can lead to the development of magnesium deficiency in the body.
Impact on the ability to drive vehicles and machinery
The drug does not have a negative effect on driving vehicles and performing potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Active ingredient
Magnesium, Pyridoxine
Composition
Active ingredients
Magnesium lactate dihydrate – 470 mg
in terms of magnesium (Mg2+) – 48 mg
Pyridoxine hydrochloride – 5 mg
Excipients:
Sucrose (white sugar) – 27.4 mg, kaolin – 41.0 mg, acacia gum (gum arabic) – 25.0 mg, Kollidon SR [polyvinyl acetate 80%, povidone (K 30) 19%, sodium lauryl sulfate 0.8%, silicon dioxide 0.2%] – 34.0 mg, magnesium stearate – 6.8 mg, carmellose sodium – 34.0 mg, talc – 6.8 mg.
Shell composition: sucrose (white sugar) – 166.7 mg, kaolin – 54.0 mg, gelatin – 0.9 mg, acacia gum (gum arabic) – 4.0 mg, beeswax – 0.4 mg, titanium dioxide – 9.0 mg, talc – 15.0 mg.
Pregnancy
Pregnancy
Clinical experience has not revealed fetotoxic or fetal malformation effects. Magnelis® B6 can be used during pregnancy only as prescribed by a doctor.
Breastfeeding period
Magnesium passes into breast milk. The use of the drug should be avoided during breastfeeding.
Contraindications
Hypersensitivity to the components of the drug, severe renal failure (creatinine clearance less than 30 ml/min), sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption.
Children’s age – up to 6 years.
With caution: in case of moderate renal failure, as there is a risk of developing hypermagnesemia.
Side Effects
From the gastrointestinal tract: abdominal pain, constipation, nausea, vomiting, flatulence.
Allergic reactions: allergic reactions to the components of the drug are possible.
Interaction
The simultaneous use of drugs containing phosphates or calcium salts can significantly reduce the absorption of magnesium in the gastrointestinal tract.
Magnesium preparations reduce the absorption of tetracycline; it is recommended to separate the administration of these drugs at three-hour intervals.
Magnesium weakens the effect of oral thrombolytic agents and reduces the absorption of iron.
Vitamin B6 inhibits the activity of levodopa.
Overdose
With normal renal function, oral magnesium does not cause toxic reactions. Magnesium poisoning can develop due to kidney failure. Toxic effects mainly depend on serum magnesium levels.
Symptoms of overdose: drop in blood pressure, nausea, vomiting, slowed reflexes, anuria, respiratory depression, coma, cardiac arrest.
Treatment: rehydration, forced diuresis. In case of renal failure, hemodialysis or peritoneal dialysis is necessary.
Storage conditions
At a temperature not higher than 25 oC.
Keep out of the reach of children.
Shelf life
3 years.
Manufacturer
Pharmstandard-UfaVITA, Russia
Shelf life | 3 years. |
---|---|
Conditions of storage | Temperature not exceeding 25 oC. Keep out of reach of children. |
Manufacturer | Pharmstandard-UfaVITA, Russia |
Medication form | pills |
Brand | Pharmstandard-UfaVITA |
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