Magne B6 forte, 30 pcs.
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Magnesium is a vital element that is necessary for the normal functioning of cells and is involved in most metabolic reactions.
In particular, it is involved in the regulation of nerve impulse transmission and muscle contraction. 1/3 of the amount of magnesium in the body is stored in bone tissue. The body gets magnesium with food. Lack of magnesium in the body can be observed when the diet is disturbed (diet) or when the need for magnesium increases.
Pyridoxine (vitamin B6) is involved in many metabolic processes, improves the absorption of magnesium from the gastrointestinal tract and its penetration into cells.
Serum magnesium levels:
- between 12 and 17 mg/L (1 – 1.4 mEq/L or 0.5 – 0.7 mmol/L): indicate moderate magnesium deficiency
- below 12 mg/L (1 mEq/L or 0.5 mmol/L): indicate severe magnesium deficiency.
Pharmacokinetics
Gastrointestinal absorption of magnesium salts occurs in part by a passive mechanism in which salt solubility plays a determining role. The degree of this absorption does not exceed 50%. Excretion occurs mainly by the kidneys.
Indications
Established magnesium deficiency, isolated or associated with other deficiency conditions, accompanied by symptoms such as increased irritability, minor sleep disturbances, gastrointestinal cramps, palpitations, increased fatigue, muscle aches and spasms, tingling sensation in muscles.
If there is no reduction in these symptoms after one month of treatment, it is not advisable to continue treatment.
Active ingredient
Composition
Active ingredients:
Magnesium citrate – 618.43 mg, which corresponds to 100 mg of magnesium (Mg++),
Pyridoxine hydrochloride – 10.00 mg;
Excipients:
Lactose – 50.57 mg,
Macrogoal-6000 – 120.00 mg,
Magnesium stearate – 1.00 mg;
Pill coating:
Hypromellose 6 mPa.c – 14.08 mg,
Macrogol-6000 – 1.17 mg,
titanium dioxide (E 171) – 4.75 mg,
talc – traces
How to take, the dosage
The tablets should be taken whole with a glass of water.
Adults: 3-4 tablets a day, divided into 2-3 doses, with meals.
Children over 6 years of age (weighing about 20 kg):
10-30 mg/kg/day (0.4-1.2 mmol/kg/day), that is, children over 6 years of age (weighing about 20 kg) 2-4 tablets daily, divided into 2-3 meals, with meals.
The duration of treatment is usually one month.
Interaction
Contraindicated combinations With levodopa: Levodopa activity is inhibited by pyridoxine (unless this drug is taken in combination with intake of peripheral aromatic L-amino acid decarboxylase inhibitors).
Pyridoxine should be avoided if levodopa is not taken in combination with peripheral aromatic L-amino acid decarboxylase inhibitors.
Unrecommended combinations
The concomitant use of drugs containing phosphates or calcium salts may impair intestinal absorption of magnesium.
Combinations to consider
If oral tetracyclines are administered, an interval of at least 3 hours between oral tetracycline and Magne B6® forte should be observed because magnesium preparations reduce tetracycline absorption.
Special Instructions
The tablets are for adults and children over 6 years of age only. In moderate renal insufficiency the drug should be taken with caution due to the risk of hypermagnesemia. If calcium and magnesium deficiency are concomitant, magnesium deficiency should be supplemented before additional calcium intake.
When using pyridoxine in high doses for a long time (for several months or in some cases – years) sensory neuropathy may develop, which is accompanied by symptoms such as numbness and vestibular disorders, tremor of distal limbs and gradually developing sensory ataxia (movement coordination disorders). These disorders are usually reversible and go away after high doses of vitamin B are withdrawn.
Contraindications
Age under 6 years (efficacy and safety have not been established).
Severe renal insufficiency (creatinine clearance less than 30 ml/min).
Hypersensitivity to any of the components of the drug.
Phenylketonuria.
Hereditary galactosemia, glucose and galactose malabsorption syndrome or lactase deficiency (due to the presence of lactose in the drug).
Concomitant use of levodopa. With caution: moderate renal insufficiency (risk of hypermagnesemia).
Side effects
Immune system disorders: allergic reactions, including skin reactions;
Gastrointestinal disorders: diarrhea, abdominal pain, nausea, vomiting, flatulence.
Overdose
Symptoms: with normal renal function, magnesium overdose when ingested does not usually cause toxic reactions. However, in cases of renal failure, magnesium poisoning may develop.
The symptoms of overdose, intensity of which depends on the concentration of magnesium in the blood: decrease of blood pressure; nausea, vomiting; depression of the central nervous system, decreased reflexes; changes on electrocardiogram; respiratory depression, coma, cardiac arrest and respiratory paralysis; anuric syndrome.
Treatment: rehydration, forced diuresis. In renal failure hemodialysis or peritoneal dialysis is necessary.
Pregnancy use
In pregnancy, the drug is taken only on the doctor’s recommendation.
Bearing in mind that magnesium penetrates into the mother’s milk, it is recommended to stop breastfeeding if the drug has to be taken.
Similarities
Weight | 0.041 kg |
---|---|
Shelf life | 2 years |
Conditions of storage | Store at a temperature not exceeding 30 C. |
Manufacturer | Hinoin Pharmaceutical and Chemical Works, Hungary |
Medication form | pills |
Brand | Hinoin Pharmaceutical and Chemical Works |
Other forms…
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