Macmiror, 200 mg 20 pcs

Macmiror is an antimicrobial, antiprotozoal, antifungal.

Pharmacodynamics

Nifuratel, antimicrobial agent of the nitrofuran group; has antiprotozoal, antifungal and antibacterial action.

Nifuratel has high efficacy and low toxicity, which leads to a wide range of its clinical use.

Highly effective against Papiliobacter and Helicobacter pylori, Gram-positive and Gram-negative microorganisms: at minimum inhibitory concentration (MIC) of 12.5-25 µg/ml it suppresses from 44.3 to 93.2% of cultures.

High activity against both aerobic and anaerobic pathogens.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteritidis, Klebsiella spp, Enterobacter spp., Serratia spp, Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical Enterobacteriaceae as well as protozoa (amebas, giardia); less active against Proteus mirabilis, Proteus vulgaris, Pseudomonas aeruginosa.

It is the drug of choice for the treatment of salmonellosis, shigellosis and other intestinal bacterial infections.

It is active against Trichomonas vaginalis, highly active against fungi of the genus Candida.

It is particularly effective against strains of Helicobacter pylori that are resistant to metronidazole.

There is evidence of high activity of nifuratel (in vitro and in vivo) against Atopobium vaginae, the main marker of bacterial vaginosis.

Pharmacokinetics

In oral administration, it is rapidly absorbed from the gastrointestinal tract. It penetrates through the BBB and the blood-placental barrier and is excreted with breast milk. It is metabolized in the liver and muscle tissue. It is completely excreted by kidneys (30-50% – unchanged), having strong antibacterial effect in the urinary tract.

Indications

Active ingredient

Composition

Active substance:

Nifuratel 200 mg;

Ancillary ingredients:

Starch;

Polyethylene glycol 6000;

talc;

Magnesium stearate;

Gelatin;

gum arabic;

sucrose;

Magnesium carbonate;

Titanium dioxide;

E wax;

How to take, the dosage

The drug is taken orally, following the recommendations.

In case of vaginal infections: adults – 1 tablet 3 times a day after meals for 7 days (both sexual partners should take the drug); for children the recommended dose is 10 mg/kg of body weight 2 times a day for 10 days.

Gastrointestinal infections associated with Helicobacter pylori: adults – 2 tablets 2 times a day for 7 days; for children the recommended dose is 15 mg/kg of body weight 2 times a day for 7 days. The duration of the course may vary depending on the chosen eradication regimen.

In intestinal amoebiasis: adults – 2 tablets 2-3 times a day for 10 days; children – 10 mg/kg body weight 3 times a day. The course of treatment is 7-10 days.

In case of giardiasis: adults – 2 tablets 2-3 times a day for 7 days; children – 15 mg/kg body weight 2 times a day for 7 days.

In case of urinary tract infections: for adults, depending on the severity of the disease, 3-6 tablets daily for 7-14 days; for children the recommended dose is 15-30 mg/kg of body weight 2 times a day for 7-14 days. The course of treatment of urinary tract infections may be prolonged or repeated according to the doctor’s recommendation.

Interaction

It enhances the antifungal effect of nystatin.

Special Instructions

In monotherapy of vaginal infections with Macmiror, it is recommended to increase the daily dosage to 4-6 tablets. During treatment, abstain from sexual intercourse.

Impact on the ability to drive or other mechanisms: No adverse effect was found.

Contraindications

Hypersensitivity to the active ingredient or any component of the drug.

Side effects

Dyspeptic disorders: nausea, vomiting, bitter mouth, diarrhea, heartburn, gastralgia.

Allergic reactions: skin rash, itching.

Similarities