Lorinden C, ointment 15 g

Lorinden C is a drug with antibacterial, antifungal and anti-inflammatory action for external use.

Flumetazon is a synthetic bifluorinated GCS for external use. It has anti-inflammatory, anti-allergic, antipruritic, anti-edema and vasoconstriction effects.

When applied to the skin it prevents marginal accumulation of neutrophils, which leads to a decrease in inflammatory exudate and lymphokine production, inhibition of macrophage migration, reduction of infiltration and granulation processes. It reduces production of prostaglandins and leukotrienes by inhibition of phospholipase A2 activity and reduction of arachidic acid release from cell membrane phospholipids.

Causes reduction of connective tissue basic substance, attenuates proliferative and exudative reactions in the skin. It is an inhibitor of cellular kinins which have proteolytic activity.

Clioquinol (iodochloroxyquinoline) is a derivative of 8-oxyquinolines. It is active against dermatophytes, yeast fungi (Microsporum spp., Trichophyton spp., Candida albicans) and gram-positive bacteria (Staphylococcus spp., Enterococcus spp.).

It enhances the anti-exudative effect of flumetasone.

As a result of the combined action of flumetasone and clioquinol (iodochloroxyquinoline) the drug suppresses the development of inflammatory-allergic reactions from the skin, complicated by bacterial and fungal infection.

The fatty base of Lorinden C ointment has a soothing effect, has water-repellent properties and forms a protective film that protects the skin from the effects of external moisture. Thanks to the nature of the ointment base the drug can be used in patients with dry and thinning skin.

Indications

Allergodermatosis, complicated by the accession of bacterial infection caused by microorganisms sensitive to clioquinol:

Bacterial and fungal skin infections complicated by local allergic reactions:

Active ingredient

How to take, the dosage

The drug must not be used for more than 2 weeks. If there is a need to use a dressing, a dressing that is breathable should be used. If there is excessive lichenization and hyperkeratosis, apply the ointment only under an occlusive dressing once every 24-48 hours. The drug should not be used for more than 1 week.

If not necessary, do not apply more than 2 g of ointment over a 24-hour period.

In adolescents after 10 years of age, use only exceptionally on limited areas of skin, avoid application to the face.

Interaction

Vaccinations and immunizations should not be performed during therapy with Lorinden C due to the immunosuppressive effect of the drug.

The drug should not be prescribed in combination with other drugs for external use.

When the drug is absorbed into the systemic bloodstream, flumetazone reduces the effectiveness of insulin, oral hypoglycemic agents, antihypertensive drugs, anticoagulants, reduces the serum concentration of salicylates and praziquantel.

When used together there is an increased risk of side effects of androgens, estrogens, oral contraceptives, anabolic steroids (hirsutism, acne);

Antipsychotics, bucarban, azathioprine (cataracts);

Choline blockers, antihistamines, tricyclic antidepressants, nitrates (glaucoma); diuretics (hypokalemia), cardiac glycosides (digitalis intoxication).

Special Instructions

With caution is used in mycosis of the skin.

Contraindications

Side effects

Contact eczema;

allergy symptoms (mainly in persons with existing allergic diseases – eczema, shingles ulcers, etc.).);

aggravation of existing changes in common or pink acne; papular or erythematous manifestations resistant to any treatment (with long-term use);

Post-steroidal acne, purpura, telangiectasia, skin atrophy and distension, perioral dermatitis, dry mouth, hypopigmentation.

Overdose

Cases of overdose are rare.

Symptoms: Inappropriate, frequent or prolonged use in significant amounts over large areas may cause systemic GCS side effects.

Treatment: gradual withdrawal of the drug; symptomatic therapy.