Loperamide, tablets 2 mg 10 pcs

Pharmaceutical group:

Antidiarrheal agent.

Pharmic action:

Loperamide, by binding to intestinal wall opioid receptors (stimulation of choline and adrenergic neurons via guanine nucleotides), reduces intestinal smooth muscle tone and motility (by inhibiting acetylcholine and PG release).

Slows down peristalsis and increases the time of passage of intestinal contents. It increases tone of anal sphincter, promotes retention of feces and reduces urges to defecation. The action develops quickly and lasts for 4-6 hours.

Active ingredient

Composition

1 tablet contains:

Active ingredient:

Loperamide hydrochloride 2 mg;

Associates:

granulac-70,

potato starch,

calcium stearate.

How to take, the dosage

Orally (capsules – without chewing, with water; lingual tablet – on the tongue, within a few seconds it disintegrates, after which it is swallowed with saliva, without water).

In acute diarrhea, adults are prescribed an initial dose of 4 mg; then 2 mg after each act of defecation (in case of liquid feces); the highest daily dose is 16 mg.

When administered in drops: the initial dose is 60 drops of 0.002% solution; then 30 drops after each act of defecation; the maximum dose is 180 drops/day (for 6 times).

In chronic diarrhea, adults are prescribed 4 mg/day. The maximum daily dose is 16 mg.

In acute diarrhea, children over 5 years of age are prescribed an initial dose of 2 mg, then 2 mg after each act of defecation; the maximum daily dose is 8 mg.

Drops: the initial dose is 30 drops of 0.002% solution; then 30 drops 3 times daily; maximum dose is 120 drops/day (4 doses).
In chronic diarrhea in children over 5 years old loperamide is indicated in daily dose of 30 drops or 2 mg.

In children aged 2-5 years old it is prescribed in solution for oral administration in 5 ml (1 measuring cap) per 10 kg; the number of administration – 2-3 times per day. Maximum daily dose is 6 mg per 20 kg. If normal stools appear or in absence of stools for more than 12 hours the drug is discontinued.

Special Instructions

If there is no effect after 2 days of treatment, it is necessary to clarify the diagnosis and rule out an infectious genesis of the diarrhea.

In children under 5 years of age it is not recommended to prescribe in capsules.

If constipation or bloating develops during treatment, loperamide should be stopped.

In patients with impaired liver function, signs of toxic CNS damage should be monitored closely.

The loss of fluids and electrolytes must be replenished during treatment of diarrhea.

During treatment, caution should be exercised while driving vehicles and engaging in other potentially hazardous activities that require increased concentration and quick psychomotor reactions.

Contraindications

Hypersensitivity, intestinal obstruction, acute ulcerative colitis, diarrhea against pseudomembranous enterocolitis, dysentery and other GI infections;
pregnancy (I trimester), lactation, children (under 2 years).
With caution. Liver failure.

Side effects

Allergic reactions (skin rash), drowsiness, dizziness, hypovolemia, electrolyte disorders; dry mouth, intestinal colic, gastralgia, pain or discomfort in the stomach, nausea, vomiting, constipation, flatulence.

Rarely – urinary retention, extremely rare – intestinal obstruction.

When taking oral tablets, a feeling of burning or tingling of the tongue.

Overdose

Symptoms: CNS depression (stupor, coordination disorders, drowsiness, miosis, muscle hypertonia, respiratory depression), intestinal obstruction.

Treatment: the antidote is naloxone; given that the duration of action of loperamide is longer than that of naloxone, reintroduction of the latter is possible. Symptomatic treatment, activated charcoal, gastric lavage, EVI.

Similarities