Loperamide, 2 mg capsules 20 pcs

Pharmacotherapeutic group: Antidiarrheal agent

Pharmacological action

Antidiarrheal agent. It decreases tone and motility of intestinal smooth muscle, apparently at the expense of binding to opioid receptors in the intestinal wall. It inhibits release of acetylcholine and prostaglandins, reducing peristalsis and increasing time of passage of contents through the intestine.

Enhances the tone of the anal sphincter. The action comes quickly and lasts for 4-6 hours.

Indications

Active ingredient

Composition

How to take, the dosage

Interaction

It is believed that concomitant use of colestyramine may decrease the efficacy of loperamide.

Concomitant use with co-trimoxazole, ritonavir increases bioavailability of loperamide due to inhibition of its metabolism during “first passage” through the liver.

In case of loperamide overdose, naloxone is used as an antidote.

Special Instructions

With caution, use in hepatic insufficiency.

Do not use in clinical situations where suppression of intestinal peristalsis is required.

If there is no effect after 2 days of using loperamide, the diagnosis should be clarified and the infectious genesis of the diarrhea should be excluded.

With caution, use in patients with hepatic impairment.

In case of loperamide overdose, naloxone is used as an antidote.

Contraindications

Side effects

Digestive system disorders: abdominal pain, bloating, nausea, constipation, dry mouth.

CNS disorders: increased fatigue, drowsiness, dizziness.

Allergic reactions: skin rash.

Overdose

Pregnancy use

It is contraindicated in the first trimester of pregnancy. In II and III trimesters of pregnancy, loperamide may be prescribed in cases when the expected benefit of therapy for the mother exceeds the potential risk to the fetus.

Because a small amount of loperamide is found in breast milk, administration during breastfeeding is not recommended.

Similarities