Lomilan, tablets 10 mg 10 pcs

Lomilan is an antihistamine, anti-allergic.

Pharmacodynamics

Loratadine refers to antihistamine drugs of systemic action, blockers of H1-histamine receptors. It has anti-allergic, antipruritic, antiexudative action. It reduces capillary permeability, prevents the development of tissue edema, relieves spasms of smooth muscles. Antiallergic effect shall develop within 30 minutes after the drug intake, it reaches its maximum effect after 8-12 hours and lasts for 24 hours.

It does not affect CNS and is not addictive.

Pharmacokinetics

Loratadine is quickly and completely absorbed from the gastrointestinal tract. The presence of food slows absorption.Cmax in serum is reached within 1 h after ingestion. Binding to plasma proteins is more than 95%. It is metabolized in the liver with the formation of the active metabolite descarboethoxyloratadine.

It does not penetrate through the BBB. T1/2 is about 8 hours, in the elderly and in chronic alcoholism it increases. It is excreted with the bile and the kidneys.

In chronic renal failure and hemodialysis the pharmacokinetics is almost unchanged.

Indications

Prevention and treatment of the following diseases and conditions:

Active ingredient

Composition

Active ingredient:

Loratadine 10 mg;

Ancillary substances:

Lactose, 71.3 mg;

Corn starch, 15 mg;

gelatinized starch, 3 mg;

magnesium stearate, 0.7 mg

How to take, the dosage

At the mouth with water or milk, can be taken with food. If necessary, the tablet may be chewed.

Adults and children over 12 years of age – 2 dosage spoons (10 ml) once a day; children from 2 to 12 years of age with body weight over 30 kg – 2 dosage spoons (10 ml) once a day; with body weight less than 30 kg – 1 dosage spoon (5 ml) once a day.

Adults and children over 12 years of age – 10 mg (1 tablet) 1 time daily; children from 3 to 12 years of age with body weight over 30 kg – 10 mg (1 tablet) 1 time daily; with body weight less than 30 kg – 5 mg (1/2 tablet) 1 time daily.

In patients with hepatic impairment a reduced daily dose for adults and children with body weight over 30 kg the dose is 10 mg (2 dosage spoons of suspension or 1 tablet) once daily.

In children under 12 years of age the use of the suspension is recommended.

The duration of treatment depends on the duration of manifestation of symptoms of the disease. If the patient’s condition does not improve within 3 days after the start of treatment, then loratadine is ineffective.

Patients of advanced age or with renal insufficiency do not require dose adjustment.

Patients with severe renal insufficiency (creatinine Cl In adults and children from 6 years of age, the starting dose should be 10 mg (2 dosage spoons of suspension or 1 tablet) every other day; in children from 3 years, 5 mg (1 dosage spoon of suspension or 1/2 tablet) every other day.

Interaction

Concomitant use of microsomal oxidation inducers (phenytoin, ethanol, barbiturates, rifampicin, tricyclic antidepressants) reduces the effectiveness of loratadine.

Possible interaction of the drug with cytochrome isoenzyme inhibitors such as CYP3A4 or CYP2D6 (ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine) increases the plasma concentration of Lomilan®, which may increase the side effects of the drug

Possible interaction of the drug with cytochrome isoenzyme inhibitors such as CYP3A4 or CYP2D6 (ketoconazole, quinidine, itraconazole, erythromycin, fluoxetine).

Contraindications

With caution: hepatic failure; severe renal failure (creatinine cl).

Side effects

Immune system disorders: very rare – anaphylactic reactions.

Nervous system disorders: often – headache, drowsiness, increased nervous excitability, increased fatigue; infrequently – insomnia; very rarely – dizziness.

Systemic system disorders: very rarely – tachycardia, palpitations, syncope, arrhythmia.

Gastrointestinal disorders: infrequent – increase of appetite; very rare – nausea, dry mouth, gastritis.

Liver and biliary tract disorders: very rare – liver function disorders.

The skin: very rare – allergic reactions (rash), alopecia.

Overdose

Symptoms: headache, drowsiness, palpitations, which may last for a long time.

Treatment: In case of taking an excessive amount of the drug Lomilan® it is recommended to wash the stomach and prescribe an adsorbent (activated charcoal). There is no specific antidote. Lomilan® is not excreted with hemodialysis.

To date it is also unknown whether Lomilan® is excreted by peritoneal dialysis. Medical follow-up of the patient should be performed after emergency therapy.

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