Locoid Lipocrem, cream 0.1% 30 g
€9.16 €8.02
Pharmgroup:
Glucocorticosteroid for topical use.
Pharmic action:
Locoid Lipocrem is a synthetic nonhalogenated glucocorticoid drug for topical use. The esterification of the hydrocortisone molecule with an oily acid residue (butyrate) allowed to radically increase the activity of the drug compared to the native hydrocortisone. It has a rapid onset anti-inflammatory, anti-edematous, antipruritic effect.
The administration of Locoid Lipocrem® in recommended doses does not cause suppression of the hypothalamic-pituitary-adrenal system. Although use of the drug in high doses over a long period of time, especially with occlusive dressings, may increase plasma cortisol levels, this is not usually accompanied by a decrease in pituitary-adrenal reactivity, and withdrawal of the drug results in a rapid normalization of cortisol production.
Pharmacokinetics:
Absorption
After application, the active substance accumulates in the epidermis, mainly in the granular layer. Systemic absorption is insignificant. A small amount of hydrocortisone 17-butyrate is absorbed into the systemic bloodstream unchanged.
Metabolism
Most hydrocortisone 17-butyrate is metabolized to hydrocortisone and other metabolites directly in epidermis and subsequently in liver.
Elimation
Metabolites and a small portion of unchanged hydrocortisone 17-butyrate are excreted with the kidneys and through the intestine.
Indications
Superficial, non-infectious, sensitive to local GCS skin diseases:
– eczema;
– dermatitis (including atopic, contact, seborrheic);
– psoriasis.
Active ingredient
Composition
1 g contains hydrocortisone 17-butyrate 1 mg,
excipients:
liquid paraffin – 180 mg,
white soft paraffin – 420 mg,
cetostearyl alcohol – 60 mg,
cetomacrogol 25 – 30 mg,
propyl parahydroxybenzoate – 0.5 mg,
benzyl alcohol – 5 mg,
citric acid anhydrous – 1.8 mg,
sodium citrate anhydrous – 1.2 mg,
purified water – 300.5 mg.
How to take, the dosage
Locoid is used topically.
The affected skin surface is smeared thinly no more than 3-4 times a day. The course of treatment is 1-3 weeks. The dose of the drug used for 1 week should not exceed 30-60 g.
In case of itching in the anus area before applying the drug the affected area should be washed with warm water and soap, then water and dry the skin surface with a towel or tissue.
For blistering skin conditions, lesions on the scalp, a lotion and emulsion for external use are used.
Special Instructions
Avoid getting the ointment in the eyes.
In children under 12 years of age the drug is prescribed only under strict medical supervision. If there is no improvement or worsening after 7 days or if symptoms return within a few days of discontinuation, discontinue use and consult a physician.
The drug should not be used without consulting a physician in cases where itching in the genital area in women is accompanied by vaginal discharge.
If prolonged treatment and/or application to large surfaces, it is recommended to prescribe a diet with restriction of Na+ and increased K+ content; to introduce sufficient protein into the body. BP, blood glucose and cortisol concentrations, blood clotting, diuresis, and the patient’s body weight should be monitored.
Contraindications
– bacterial skin infections (strepto- and staphylodermia, gram-negative folliculitis);
– viral skin infections (herpes simplex, varicella, herpes zoster);
– fungal skin infections;
– tuberculosis and syphilitic skin lesions;
– parasitic skin infections;
– neoplastic skin changes (benign and malignant tumors);
– acne, rosacea, perioral dermatitis;
– postvaccination period;
– skin integrity disorders (wounds, ulcers);
– hypersensitivity to the preparation “Locoid Lipokrem.
The drug should be used with caution during pregnancy and lactation.
Side effects
Local reactions: skin irritation; in rare cases – other local reactions typical for GCS therapy.
Systemic reactions: with prolonged use, application to large surfaces and/or use of occlusive dressings, side effects typical of systemic GCS may be observed.
The risk of local and systemic side effects with Lipocrem® Locoid is lower than with fluorinated steroids.
Similarities
Weight | 0.045 kg |
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Shelf life | 2 years. |
Conditions of storage | The drug should be kept out of reach of children at a temperature not exceeding 25°C. |
Manufacturer | Temmler Italia S.r.l., Italy |
Medication form | exterior cream |
Brand | Temmler Italia S.r.l. |
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