Livazo, 2 mg 28 pcs.
€30.25 €26.21
Pitavastatin competitively inhibits HMG-CoA reductase, limiting the rate of action of the enzyme in cholesterol biosynthesis, inhibits the synthesis of cholesterol (Chs) in the liver. As a consequence, LDL receptor expression in the liver is increased, contributing to the uptake of circulating LDL in the blood, lowering total Chs and LDL cholesterol (Chs-LDL) in the blood. Its persistent inhibition of hepatic Chs synthesis reduces LDL secretion into the blood, lowering plasma triglyceride levels.
Indications
Primary hypercholesterolemia, including heterozygous familial hypercholesterolemia (Fredrickson type IIa hyperlipidemia) or mixed hypercholesterolemia (Fredrickson type IIb hyperlipidemia), hypertriglyceridemia (Fredrickson type IV hyperlipidemia) as an adjunct to diet, when diet and other non-medicinal treatments (e.g., exercise, weight loss) are insufficient.
Active ingredient
Pitavastatin
How to take, the dosage
Orally, the tablets should be swallowed whole.
Interaction
Cyclosporine: A 4.6-fold increase in the AUC of pitavastatin was observed when a single dose of cyclosporine was administered simultaneously with Livazo in equilibrium. Livazo is contraindicated in patients treated with cyclosporine.
Contraindications
Severe hepatic impairment (more than 9 points on the Child-Pugh scale) or Child-Pugh class C, liver disease and active phase, including persistent increase in serum hepatic transaminase activity (more than 3 times of HGH); myopathy; concomitant use of cyclosporine; pregnancy, breastfeeding, absence of adequate methods of contraception in women of childbearing age; age under 18 years (efficacy and safety are not established); hypersensitivity to pitavastatin, excipients of the preparation and other HMG-CoA reductase inhibitors (statins).
Side effects
Frequency is defined as: very frequently (≥1/10), frequently (≥1/100 to < 1/10), infrequently (≥1/1000 to < 1/100), rarely (≥1/10 000 to < 1/1000), very rarely (< 1/10 000) and unknown.
Overdose
An overdose may increase the symptoms of adverse reactions.
Weight | 0.019 kg |
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Shelf life | 4 years. |
Conditions of storage | The drug should be stored in the original package in a light-protected place out of reach of children at a temperature not exceeding 25 ° C. |
Manufacturer | Pierre Fabre Medical Production, France |
Medication form | pills |
Brand | Pierre Fabre Medical Production |
Other forms…
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