Livarol, vaginal suppositories 400 mg 5 pcs

The active ingredient is ketoconazole, a derivative of imidazoldioxolane.

It has fungicidal and fungostatic effect against dermatophytes (Trichophyton spr., Eridermophyton floccosum, Microsporum spr.) and yeasts (Candida spr., Pityrosporum spr.).

The mechanism of action is inhibition of ergosterol biosynthesis and changing lipid composition of the fungal membrane.

The drug is active against staphylococci and streptococci.

Pharmacokinetics

Systemic absorption with intravaginal use is negligible.

Indications

Active ingredient

Composition

Active ingredient:

Ketoconazole – 400 mg;

Auxiliary substances:

Butylhydroxyanisole.

The base for the suppositories:

Macrogol 1500 (polyethylene oxide 1500),

Macrogol 400 (polyethylene oxide 400) – enough to produce a suppository weight of 3.0 g.

How to take, the dosage

Pre-release the suppository from the contour pack and insert it deep into the vagina in the supine position for 1 suppository per day for 3-5 days depending on the course of the disease.

In chronic candidiasis 1 suppository is used for 10 days.

Interaction

In the use of Livarol® vaginal suppositories 400 mg, negative interactions with other drugs are not known and should not be expected because the resorption capacity of ketoconazole is low.

Contraindications

High sensitivity to the components of the drug. Pregnancy (I trimester).

With caution: pregnancy (II-III trimester), lactation, children under 12 years of age.

Side effects

Hyperemia and irritation of the vaginal mucosa, vaginal itching.

Allergic reactions: skin rash, urticaria.

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