Linex Forte, capsules 14 pcs

Pharmacotherapeutic group

Eubiotic. ATX code: A07FA51

Pharmacological Properties

.Pharmacodynamics

Linex® Forte normalizes intestinal microflora. One capsule of Linex® Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12)); each capsule contains 109 colony forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal component of the natural intestinal microflora. The main functions of lactic acid bacteria:

• protective: synthesis of substances with antibacterial activity
• enzyme-producing: hydrolysis of fiber, proteins, fats, starch, deconjugation of bile acids
• synthetic: synthesis of vitamins B, C, K, amino acids, organic acids, etc.д. Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:
• lowering the pH in the gut (a result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);
• producing metabolites that have toxic effects against pathogenic bacteria (H2O2 formation);
• competes with pathogenic bacteria for nutrients;
• interacting with adhesion receptors, thus preventing colonization by other, potentially pathogenic microorganisms.

Pharmacokinetics

Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract and the drug is not systemically absorbed when ingested. Standard pharmacokinetic studies are therefore not applicable.

The resistance of LA-5 and BB- 12 to gastric juice and bile allows the strains to survive in large numbers as they pass through the stomach and 12 duodenum. Both strains attach to the intestinal mucosa. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.

Indications

Treatment and prevention of intestinal dysbacteriosis.

Gut dysbacteriosis has the following symptoms: diarrhea (diarrhea), dyspepsia (digestive disorders), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.

Active ingredient

Composition

1 capsule contains:

The active ingredient:

Probiotec® AB Blend 64 (Probio-tec® AB Blend 64) powder – 60,000 mg (the powder contains the active ingredients: Lactobacillus acidophilus (LA-5) – 13.8 mg and Bifidobacterium animalis subsp. lactis (BB-12) – 4.2 mg;

auxiliary components:

anhydrous dextrose – 29.1 mg,

microcrystalline cellulose – 6 mg,

How to take, the dosage

Linex® Forte capsules are recommended to be taken during or after meals with a small amount of liquid.

Adults and adolescents over 12 years of age: 1 capsule 1 to 3 times a day.

Children from 2 to 12 years of age: 1 capsule 1 to 2 times a day.

Infants and children under 2 years of age: 1 capsule 1 time a day.

Diarrhea in children under 6 years of age must be treated under medical supervision.

If Linex® Forte is prescribed to children and patients who cannot swallow the whole capsule, the capsule must be opened, the contents poured into a spoon and mixed with a small amount of fluid.

The duration of treatment depends on the cause of dysbacteriosis and the individual characteristics of the body. The drug Linex® Forte can be taken until the symptoms of dysbacteriosis disappear.

The recommended daily doses of the drug should not be exceeded.

Interaction

No undesirable interaction with other medicinal products was noted.

In case of concomitant use of antibiotics, the recommended interval between the drug (antibiotic) and Linex® Forte capsules is 3 hours.

Special Instructions

Do not take Linex® Forte with hot drinks and do not take it with alcohol.

Please consult your doctor before taking the drug if you have:

The treatment of diarrhea requires replenishment of lost fluids and electrolytes.

Contraindications

– Hypersensitivity to the components of the drug;

– hereditary intolerance to fructose, deficiency of sucrose, isomaltase or glucose-galactose malabsorption.

WARNING

With caution in diabetes mellitus (contains simple sugars), immune system deficiencies (e.g., HIV infection). Diarrhea in children younger than 6 years should be treated under the supervision of a doctor.

Side effects

The drug is well tolerated.

There have been no reports of adverse effects, but hypersensitivity reactions may occur.

Overdose

There are no data on the symptoms of overdose.