Linex Forte, capsules 14 pcs
€16.99 €14.16
Pharmacotherapeutic group
Eubiotic. ATX code: A07FA51
Pharmacological Properties
.Pharmacodynamics
Linex® Forte normalizes intestinal microflora. One capsule of Linex® Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12)); each capsule contains 109 colony forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal component of the natural intestinal microflora. The main functions of lactic acid bacteria:
- protective: synthesis of substances with antibacterial activity
- enzyme-producing: hydrolysis of fiber, proteins, fats, starch, deconjugation of bile acids
- synthetic: synthesis of vitamins B, C, K, amino acids, organic acids, etc.д. Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:
- lowering the pH in the gut (a result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);
- producing metabolites that have toxic effects against pathogenic bacteria (H2O2 formation);
- competes with pathogenic bacteria for nutrients;
- interacting with adhesion receptors, thus preventing colonization by other, potentially pathogenic microorganisms.
Pharmacokinetics
Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract and the drug is not systemically absorbed when ingested. Standard pharmacokinetic studies are therefore not applicable.
The resistance of LA-5 and BB- 12 to gastric juice and bile allows the strains to survive in large numbers as they pass through the stomach and 12 duodenum. Both strains attach to the intestinal mucosa. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.
Indications
Treatment and prevention of intestinal dysbiosis.
Intestinal dysbiosis is manifested by the following symptoms: diarrhea (diarrhea), dyspepsia (indigestion), constipation, flatulence (bloating), nausea, belching, vomiting, abdominal pain, allergic skin reactions are possible.
Pharmacological effect
PHARMACOTHERAPEUTIC GROUP
Eubiotic. ATX code: A07FA51
PHARMACOLOGICAL PROPERTIES
Pharmacodynamics
Linex® Forte normalizes intestinal microflora. One capsule of Linex® Forte contains lactic acid bacteria (Lactobacillus acidophilus (LA-5) and Bifidobacterium animalis subsp. lactis (BB-12)), each capsule contains 109 colony-forming units of live lyophilized lactic acid bacteria. Live lactic acid bacteria are a normal part of the natural intestinal microflora. The main functions of lactic acid bacteria:
protective: synthesis of substances with antibacterial activity;
enzyme-producing: hydrolysis of fiber, proteins, fats, starch, deconjugation of bile acids
synthetic: synthesis of vitamins B, C, K, amino acids, organic acids, etc. Lactic acid bacteria LA-5 and BB-12 inhibit the growth of pathogenic bacteria by:
decreased intestinal pH (a result of the ability of LA-5 to synthesize lactic acid and BB-12 to synthesize acetic and succinic acids in addition to lactic acid);
production of metabolites that have a toxic effect on pathogenic bacteria (formation of H2O2);
formation of antimicrobial substances, bacteriocins (LA-5 secretes acidocin, a broad-spectrum bacteriocin that prevents the growth of bacteria and fungi);
competition with pathogenic bacteria for nutrients;
interaction with adhesion receptors, thus preventing the colonization of other, potentially pathogenic microorganisms.
Pharmacokinetics
Lactic acid bacteria, such as LA-5 and BB-12, act directly in the gastrointestinal tract; when taken orally, the drug is not subject to systemic absorption. Standard pharmacokinetic studies are therefore not applicable.
The resistance of LA-5 and BB-12 to gastric juice and bile allows the strains to survive in large numbers when passing through the stomach and duodenum. Both strains attach to the intestinal lining. Like other microorganisms, they are gradually eliminated from the gastrointestinal tract by peristalsis and defecation.
Special instructions
Linex® Forte should not be washed down with hot drinks or taken simultaneously with alcohol.
You should consult your doctor before taking the drug if you:
body temperature above 38 °C;
traces of blood or mucus in the stool;
diarrhea lasts more than two days and is accompanied by severe abdominal pain, dehydration and weight loss;
chronic diseases – diabetes, HIV infection.
When treating diarrhea, it is necessary to replace lost fluids and electrolytes.
Active ingredient
Lactobacillus acidophyllus, Bifidobacterium BB12
Composition
1 capsule contains:
Active ingredient:
Probio-tec AB Blend 64 powder (Probio-tec® AB Blend 64) – 60,000 mg (powder contains active ingredients: Lactobacillus acidophilus (LA-5) – 13.8 mg and Bifidobacterium animalis subsp. lactis (BB-12) – 4.2 mg;
auxiliary components:
dextrose anhydrous – 29.1 mg,
microcrystalline cellulose – 6 mg,
potato starch 6 – mg,
magnesium stearate – 0.9 mg).
Excipients:
Beneo Synergy 1 (Beneo® Synergy 1) – 171,500 mg (powder contains 90-94% inulin and 6-10% oligofructose (dextrose + fructose + sucrose)); magnesium stearate – 3,500 mg.
Composition of the capsule body:
hypromellose – 33.149 mg, titanium dioxide (E 171) – 0.691 mg. Composition of the capsule cap: hypromellose – 22.080 mg, titanium dioxide dye (E 171) – 0.240 mg, yellow iron oxide dye (E 172) – 0.240 mg.
Contraindications
– Hypersensitivity to the components of the drug;
– hereditary fructose intolerance, deficiency of sucrase, isomaltase or glucose-galactose malabsorption.
WITH CAUTION
With caution in case of diabetes mellitus (contains simple sugars), immune system deficiency (for example, HIV infection). Diarrhea in children under 6 years of age should be treated under medical supervision.
Side Effects
The drug is well tolerated.
There are no reports of adverse effects, but hypersensitivity reactions may occur.
Interaction
No undesirable interactions with other drugs were noted.
When using antibiotics simultaneously, the recommended interval between taking the drug (antibiotic) and Linex® Forte capsules is 3 hours.
Overdose
There are no data on overdose symptoms.
Storage conditions
Store at a temperature not exceeding 25°C, out of the reach of children.
Shelf life
2 years.
Manufacturer
Lek d.d., Slovenia
Shelf life | 2 years. |
---|---|
Conditions of storage | Store at a temperature not exceeding 25 ° C, out of the reach of children. |
Manufacturer | Lek d.d., Slovenia |
Medication form | capsules |
Brand | Lek d.d. |
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