Licorice root syrup 100 g

The remedy is of plant origin. Licorice root contains glycyrrhizin (6 to 12%), glycyrrhizic acid and its salts, flavone glycosides (liquiritin, liquiritigenin, liquiritoside), isoflavonoids (formononetin, glabrin, glabridin, glabrol, 3-hydroxyglabrol, glycyrrhizoflavone), coumestane derivatives (glycyrol, isoglycyrol, liquocoumarin), hydroxycoumarins (incl.including gerniarin, umbelliferon, glycocoumarin, lycopyranocoumarin), steroids (sterols, including beta-sitosterol, sigmasterol), essential oils (in small amounts).

Glycyrrhizin stimulates the activity of ciliated epithelium and increases the secretory function of mucous membranes of the upper respiratory tract, facilitates expectoration. It has anti-ulcer and anti-inflammatory effects and reduces platelet aggregation.

The licorice inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase in the kidneys, which leads to a decrease in the conversion of cortisol into cortisone. The mineralocorticoid activity of cortisol is due to a decrease in serum potassium concentration and an increase in sodium, which leads to fluid retention in the body, an increase in body weight and arterial hypertension. Glycyrrhizic acid and its metabolites inhibit peripheral cortisol metabolism and cause a pseudoaldosterone-like effect.

Liquiritoside has an antispasmodic effect on smooth muscles.

Indications

Diseases of the upper respiratory tract, lungs; hyperacid gastritis, peptic ulcer of the stomach and duodenum. Addison’s disease, hypofunction of the adrenal cortex (as part of complex therapy).

Pharmacological effect

Herbal product. Licorice root contains glycyrrhizin (from 6 to 12%), glycyrrhizic acid and its salts, flavone glycosides (liquiritin, liquiritigenin, liquiritoside), isoflavonoids (formononetin, glabrene, glabridin, glabrol, 3-hydroxyglabrol, glycyrrhizoflavone), coumestan derivatives (glycyrol, isoglycerol, liquocoumarin), hydroxycoumarins (including herniarin, umbelliferone, glycocoumarin, lycopyranocoumarin), steroids (sterols, including beta-sitosterol, sigmasterol), essential oils (in small quantities).

Glycyrrhizin stimulates the activity of the ciliated epithelium and enhances the secretory function of the mucous membranes of the upper respiratory tract, facilitating expectoration. It has antiulcer and anti-inflammatory effects, reduces platelet aggregation.

Licorice inhibits the enzyme 11-beta-hydroxysteroid dehydrogenase in the kidneys, which leads to a decrease in the conversion of cortisol to cortisone. The mineralocorticoid activity of cortisol causes a decrease in the concentration of potassium in the blood serum and an increase in sodium content, which leads to fluid retention in the body, weight gain and arterial hypertension. Glycyrrhizic acid and its metabolites inhibit the peripheral metabolism of cortisol and cause a pseudoaldosterone-like effect.

Liquiritoside has an antispasmodic effect on smooth muscles.

Special instructions

When prescribed to patients with bronchial asthma, constant monitoring is required (intolerance reactions are possible).

Active ingredient

Licorice roots

Composition

100 ml of syrup contains:

Active ingredients:

thick licorice root extract 4 g,

sugar syrup 86 g,

ethyl alcohol 96% and water up to 100 ml.

Contraindications

Increased individual sensitivity to the components of the drug,
pregnancy,
lactation period,
bronchial asthma,
gastritis,
peptic ulcer of the stomach and duodenum during an exacerbation.

With caution: liver disease, alcoholism, traumatic brain injury, brain disease, diabetes, childhood.

Side Effects

Nausea, heartburn, allergic reactions.

Interaction

Concomitant use of thiazide diuretics with licorice is not recommended due to the risk of hypokalemia.

Hypokalemia caused by long-term use of licorice can potentiate the toxic effect of cardiac glycosides.

With the simultaneous use of licorice and corticosteroids, an increase in the half-life of cortisol is possible.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 20 °C.

Manufacturer

Flora of the Caucasus, Russia