Levolet R, 500 mg 10 pcs.

Pharmacodynamics

Fluoroquinolone, broad spectrum antimicrobial bactericidal agent. It blocks DNA-hymerase (topoisomerase II) and topoisomerase IV, disrupts superspiralization and cross-linking of DNA breaks, inhibits DNA synthesis, causes profound morphological changes in cytoplasm, cell wall and membranes.

Levofloxacin is active against the following strains of microorganisms, both in vitro and in vivo.

Sensitive microorganisms

MAC Aerobic Gram-positive microorganisms: Corynebacterium diphtheriae, Enterococcus faecalis, Enterococcus spp, Listeria monocytogenes, Staphylococcus coagulase-negative methi-S(J) (methicillin-sensitive/moderately sensitive strains), Staphylococcus aureus methi-S (methicillin-sensitive strains), Staphylococcus epidermidis methi-S (methicillin-sensitive strains), Staphylococcus spp. Streptococci of groups C and G (including Streptococcus agalactiae, Streptococcus pneumoniae peni-S/UR (penicillin-sensitive/moderately sensitive/resistant strains)), Streptococcus pyogenes, Viridans streptococci peni-S/R (penicillin-sensitive/resistant strains).

Aerobic Gram-negative microorganisms: Acinetobacter baumannil, Acinetobacter spp, Actinobacillus actinomycetemcomitans, Citrobacter freundii, Eikenella corrodens, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter spp. (including Enterobacter cloacae), Escherichia coli, Gardnerella vaginalis, Haemophilus ducreyi, Haemophilus influenzae ampi-S/R (ampicillin-sensitive/resistant strains), Haemophilus parainfluenzae, Helicobacter pylori, Klebsiella spp. (including Klebsiella oxytoca, Klebsiella pneumoniae), Moraxela catarrhalis β+/β- (P-lactamase producing and non-producing strains), Morganella morganii, Neisseria gonorrhoeae non-PPNG/PPNG (penicillinase producing and non-producing strains), Neisseria meningitidis, Pasteurella spp. (including Pasteurella conis, Pasteurella dagmatis, Pasteurella multocida), Proteus mirabilis, Proteus vulgaris, Providencia spp. (including Providencia rettgeri, Providencia stuartii), Pseudomonas spp. (including Pseudomonas aeruginosa), Serratia spp, Serratia marcescens).

Anaerobic microorganisms: Bacteroides jragilis, Bifidobacterium spp., Clostridium perfringens, Fusobacterium spp, Peptostreptococcus spp., Propionibacterium spp., Veilonella spp.

Other microorganisms: Bartonella spp, Chlamydia pneumoniae, Chlamydia psittaci, Chlamydia trachomatis, Legionella pneumophila, Legionella spp., Mycobacterium spp. (including Mycobacterium leprae, Mycobacterium tuberculosis, Mycoplasma hominis, Mycoplasma pneumoniae), Ricketsia spp, Ureaplasma urealyticum.

Moderately susceptible microorganisms (MPC>4 mg/L):

Aerobic Gram-positive microorganisms: Corynebacterium urealiticum, Corynebacterium xerosis, Enterococcus faecium, Staphylococcus epidermidis methi-R (methicillin-resistant strains), Staphylococcus haemolyticus methi-R (methicillin-resistant strains).

Aerobic Gram-negative microorganisms: Burkholderia cepacia, Campilobacter jejuni, Campilobacter coli.

Anaerobic microorganisms: Bacteroides thetaiotaomicron, Bacteroides vulgatus, Bacteroides ovaius, Prevotella spp, Porphyromonas spp.

Resistant microorganisms (MPC>8 mg/L):

Aerobic Gram-positive microorganisms: Corynebacterium jeikeium, Staphylococcus aureus methi-R (methicillin-resistant strains), Staphylococcus coagulase-negative methi-R (coagulazonegative methicillin-resistant strains).

Aerobic Gram-negative microorganisms: Alcaligenes xylosoxidans.

Other microorganisms: Mycobacterium avium.

Pharmacokinetics

When administered orally it is quickly and almost completely absorbed (eating has little effect on the speed and completeness of absorption). Bioavailability is 99%.
Time of maximal concentration achievement (Tmax) is 1-2 hours; at intake of 250 and 500 mg averaged value of maximal concentration (Сmax) is 2.8 and 5.2 µg/ml, respectively. Binding with plasma proteins is 30-40%.

It penetrates into organs and tissues: lungs, bronchial mucosa, sputum, urogenital organs, polymorphonuclear leukocytes, alveolar macrophages. A small part is oxidized and/or deacetylated in the liver. It is eliminated from the body mainly by the kidneys by glomerular filtration and tubular secretion. The half-life (T½) is 6-8 hours.

Renal clearance is 70% of total clearance. Less than 5% of levofloxacin is excreted as metabolites. In urine it is detected unchanged 70% during 24 hours and in 48 hours – 87% of the ingested dose. In the feces, during 72 hours, 4% of the oral dose is detected.

In renal insufficiency decrease of clearance of the drug and its excretion by the kidneys depends on the degree of decrease of creatinine clearance (CK).

Indications

Active ingredient

Composition

How to take, the dosage

Special Instructions

Contraindications

Side effects

Pregnancy use

Similarities