Levofloxacin, 5 mg/ml 100 ml
€6.55 €5.73
A broad-spectrum antimicrobial agent, a fluoroquinolone. It acts bactericidally. It blocks DNA-enzyme (topoisomerase II) and topoisomerase IV, disrupts superspiralization and cross-linking of DNA breaks, inhibits DNA synthesis, causes deep morphological changes in cytoplasm, cell wall and membranes.
. Active against Enterococcus faecalis, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes and Streptococcus agalactiae, Viridans group streptococci, Enterobacter cloacae, Enterobacter aerogenes, Enterobacter agglomerans, Enterobacter sakazakii, Escherichia coli, Haemophilus influenzae, Haemophilus parainfluenzae, Klebsiella pneumoniae, Klebsiella oxytoca, Legionella pneumoniae, Moraxella catarrhalis, Proteus mirabilis, Pseudomonas aeruginosa, Pseudomonas fluorescens, Chlamydia pneumoniae, Mycoplasma pneumoniae, Acinetobacter anitratus, Acinetobacter baumannii, Acinetobacter calcoaceticus, Bordetella pertussis, Citrobacter diversus, Citrobacter freundii, Morganella morganii, Proteus vulgaris, Providencia rettgeri, Providcncia stuartii, Serratia marcescens, Clostridium perfringens.
Indications
Tuberculosis, Respiratory tract infections, maxillary sinusitis, Infectious diseases, Bronchitis, Urinary tract infections, Lung inflammation (pneumonia), Sinusitis, furuncles, Skin infectionsTherapy of mild, moderate and severe infections caused by Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarhalis strains of microorganisms sensitive to levofloxacin: acute sinusitis
Active ingredient
Levofloxacin
Composition
Active substance – levofloxacin hemihydrate (in terms of levofloxacin) – 5 g.
Auxiliary substances:
Sodium chloride – 900 mg,
Lactic acid – 25 mg,
water d/i – up to 100 ml.
Interaction
When combined treatment with phenbufen and similar NSAIDs, theophylline may increase the threshold of seizure readiness.
Directions for use
Levofloxacin is administered by IV drip slowly at 250-750 mg every 24 hours (250-500 mg dose administered within 60 minutes, 750 mg within 90 minutes). Subsequent transfer to oral administration at the same dose is possible. The duration of treatment depends on the indications for use, as well as the sensitivity of the suspected pathogen. Recommended dosing regimen should be strictly observed. It is recommended to continue using the drug for 2-3 days after normalization of body temperature. Independent interruption or premature termination of treatment with the drug is unacceptable.
Special Instructions
The drug infusion solution is compatible with the following infusion solutions: physiological solution, 5% glucose solution, 2.5% Ringer’s solution with dextrose, combined solutions for parenteral nutrition (amino acids, carbohydrates, electrolytes). Infusion solution of the drug must not be mixed with heparin or solutions with alkaline reaction (e.g. sodium bicarbonate solution).
Contraindications
Hypersensitivity to levofloxacin or other quinolones; epilepsy; tendon lesions associated with the intake of quinolones in the history; childhood and adolescence under 18 years.
Side effects
Allergic reactions: sometimes – itching and redness of the skin, rarely – anaphylactic and anaphylactoid reactions (manifested by symptoms such as urticaria, facial edema, very rare – a sudden drop in BP and shock, in some cases – Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell syndrome) and erythema exudative multiforme.
Similarities
Signicef, Tavanic, Oftavix, Flexid, Levolet R, Levofloxacin-Teva, Glevo, Haileflox, Leflobakt, L-Optik Rompharm, Levofloxacin, Korfecin
Weight | 0.225 kg |
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Manufacturer | Kraspharma PJSC, Russia |
Medication form | solution for infusion |
Brand | Kraspharma PJSC |
Other forms…
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