Leucovorin-LENS, lyophilizate 25 mg 5 pcs

Calcium folinate is a reduced form of folic acid and is used as an antidote to drugs that act as folic acid antagonists. This compound is also known as folinic acid.

Indications

Active ingredient

How to take, the dosage

The solution is administered intramuscularly or intravenously. Due to the fact that different regimens of Leucovorin-LNS are used, the doctor should be guided by special medical literature when choosing a specific dose.

In combination with high doses of methotrexate (12-15 g/m3 ), administration usually begins 24 hours after methotrexate treatment ends at a dose of 10 mg/m2 every 6 hours for 72 hours or until plasma methotrexate concentrations are less than 5×10 -8 M.

Patients with acidic urine reactions, exudative effusions, impaired renal function, or bowel obstruction may require a higher dose of Leucovorin-LNS and/or longer duration of treatment because methotrexate excretion may be delayed in this group of patients. The use of Leucovorin-LENS® in these cases is recommended to be based on obligatory determination of methotrexate concentration in blood plasma. In order to prevent development of CPN, hydration (3 liters/day) and administration of sodium bicarbonate to maintain urine pH at 7 or higher is performed.

In case of accidental methotrexate overdose Leucovorin-LENS® is administered in dose equal or higher than dose of injected methotrexate not later than 1 hour after methotrexate injection, further the drug is injected every 3 hours by 10 mg/m2 until signs of toxicity disappear. When combined with fluorouracil, Leukovorin-LNS is administered:

– at a dose of 200 mg/m2 intravenously slowly (at least 3 minutes) or intravenously drip followed by intravenous fluorouracil at a dose of 370 mg/m2 or

– at a dose of 20 mg/m2 intravenously followed by intravenous fluorouracil at a dose of 425 mg/m2.

The drugs are administered daily for 5 days with an interval of 4-5 weeks between repeated courses. In treatment of megaloblastic anemia caused by folic acid deficiency Leucovorin-LENS® is administered by 1 mg intramuscularly or intravenously per day.

Interaction

Special Instructions

Contraindications

Side effects

Overdose