Lancid, 30 mg capsules 30 pcs

Lancid is an antiulcer.

Inhibits H⁺ – K⁺ATPase (proton pump) of parietal cells, blocks the terminal stage of hydrochloric acid formation, suppresses basal and stimulated secretion.

Pharmacodynamics

With high lipophilicity, easily penetrates into the parietal cells of the stomach, concentrates in them, has cytoprotective effect, increases bicarbonate secretion. Inhibition of hydrochloric acid formation at a dose of 30 mg is 80-97%. It does not affect the motility of the gastrointestinal tract. The inhibitory effect increases in the first four days of use. Secretory activity is restored in 3-4 days after discontinuation of the drug.

Pharmacokinetics

Absorption is high. C_max after oral administration at a dose of 30 mg is reached in 1.5-2.2 h and is 0.75-1.15 mg/L. Binding to plasma proteins is 98%. T_1/2 is 1.3-1.7 h (increases with impaired renal function and in old age). It is actively metabolized during primary passage through the liver. It is excreted by the kidneys as metabolites (14-23%) and by the intestine.

Indications

Peptic ulcer of the stomach and duodenum, reflux esophagitis, erosive and ulcerative lesions of the stomach and duodenum while taking NSAIDs or associated with Helicobacter pylori (as part of complex therapy), stress ulcers, Zollinger-Ellison syndrome.

Pharmacological effect

Lancid – antiulcer.

Inhibits H+ – K+ ATPase (proton pump) of parietal cells, blocks the final stage of hydrochloric acid formation, suppresses basal and stimulated secretion.

Pharmacodynamics

Possessing high lipophilicity, it easily penetrates into the parietal cells of the stomach, concentrates in them, has a cytoprotective effect, and increases the secretion of bicarbonates. Inhibition of the formation of hydrochloric acid at a dose of 30 mg is 80–97%. Does not affect gastrointestinal motility. The inhibitory effect increases in the first four days of administration. Secretory activity is restored 3–4 days after discontinuation of the drug.

Pharmacokinetics

Absorption is high. Cmax after oral administration at a dose of 30 mg is achieved after 1.5–2.2 hours and is 0.75–1.15 mg/l. Plasma protein binding – 98%. T1/2 – 1.3–1.7 hours (increases with impaired renal function and in old age). Actively metabolized during the initial passage through the liver. Excreted by the kidneys in the form of metabolites (14–23%), as well as by the intestines.

Special instructions

Before starting treatment, it is necessary to exclude the presence of a malignant process in the upper gastrointestinal tract.

Active ingredient

Lansoprazole

Composition

1 capsule contains:

Active ingredient:

Lansoprazole – 15 mg or 30 mg.

Composition of capsule containing lansoprazole – 30 mg (body):

Gelatin – 38.9575 mg, sodium lauryl sulfate – 0.0376 mg, propyl parahydroxybenzoate – 0.37(30 mg. methyl parahydroxybenzoate – 0.0940 mg, titanium dioxide – 0.7120 mg, crimson dye [Ponceau 4R] – 0.0078 mg. water – 6.8150 mg.

Composition of a capsule containing lansoprazole – 30 mg (cap):

Gelatin – 24.0376 mg. sodium lauryl sulfate – 0.0232 mg, propyl parahydroxybenzoate – 0.0580 mg, methyl parahydroxybenzoate – 0.2320 mg, titanium dioxide – 0.4393 mg, crimson dye [Ponceau 4R] – 0.0048 mg. water – 4.2050 mg.

Composition of black ink: ethanol – 29-33%, isopropanol – 9-12%, butanol – 4-7%, shellac – 24-28%, black iron oxide dye – 24-28%. aqueous ammonia – 1-3%, propylene glycol 0.5-2%.

Pregnancy

Contraindicated. Breastfeeding should be stopped during treatment.

Contraindications

Hypersensitivity, liver and/or kidney failure, pregnancy, breastfeeding, childhood.

Side Effects

From the nervous system and sensory organs: headache, dizziness, drowsiness, in isolated cases – depression.

From the gastrointestinal tract: diarrhea, abdominal pain, constipation.

Allergic reactions: skin rashes.

From the respiratory system: rhinitis, pharyngitis.

Other: myalgia

Interaction

Slows down the elimination of drugs metabolized in the liver by microsomal oxidation (including diazepam, phenytoin, indirect coagulants). Antacids slow down and reduce absorption.

Storage conditions

In a dry place, protected from light, at a temperature not exceeding 25 °C.

Shelf life

2 years

Manufacturer

Micro Labs Limited, India